标题：不同药物治疗急性脑梗死对患者血清炎症因子的影响

      作者：王 锋 1，张素雅 1，朱 瑾 1，郭思思 1，周 叶 1，朱静嫣 1，胡春梅 1，孙 姬 2
    （1.上海宝山中西医结合医院神经内科，上海 201900；
2.上海交通大学医学院附属第三人民医院神经内科，上海 201900）

      卷次： 2015年26卷6期

      【摘要】 目的 研究阿托伐他汀和葛根素注射液治疗急性脑梗死患者期间对其血清炎症因子的影
响。方法 选择 2013年1~12月我院神经内科收治的128例急性脑梗死患者为研究对象，按照治疗方法分成A
组与B组，每组各64例，A组口服阿托伐他汀治疗，B组使用葛根素注射液治疗，比较分析两组患者的临床疗效及
血脂、血清炎症因子水平与颈动脉粥样硬化等指标变化。结果 B组的治疗有效率为 98.4%，显著优于A组的
89.1%，两组比较差异有统计学意义(P<0.05)。B组治疗后的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇
(LDL-C)、高敏Ｃ反应蛋白（hs-CRP）及基质金属蛋白酶-9（MMP-9）水平均较A组降低，高密度脂蛋白胆固醇
(HDL-C)水平升高，差异具有统计学意义(P<0.05)。B组治疗后的颈动脉内膜中层厚度(IMT)与斑块面积均低于
A组治疗后差异具有统计学意义(P<0.05)。结论 与阿托伐他汀疗效比较，葛根素注射液治疗效果更确切，抑制
血清炎症因子效果更显著，可以明显降低血脂水平及有效逆转颈动脉粥硬化。

      【关键词】 阿托伐他汀；葛根素；脑梗死；炎症因子；血脂

      【中图分类号】 R743.33 【文献标识码】 A 【文章编号】 1003—6350（2015）06—0797—03


Effects of different drugs in the treatment of patients with acute cerebral infarction on serum inflammatory
factors.
WANG Feng 1, ZHANG Su-ya 1, ZHU Jin 1, GUO Si-si 1, ZHUO Ye 1, ZHU Jing-yan 1, HU Chun-mei 1, SUN Ji 2.
1. Department of Neurology, Integrated Chinese and Western Medicine Hospital of Baoshan District of Shanghai,
Shanghai 201900, CHINA; 2. Department of Neurology, the Third People's Hospital Affiliated to Shanghai Jiao Tong
University School of Medicine, Shanghai 201900, CHINA

【Abstract】 Objective To study the effect of Ge Gensu injection (Puerarin) and atorvastatin on serum inflam-
matory factors in the treatment of acute cerebral infarction. Methods In 2013, 128 patients of acute cerebral infarc-
tion were selected. The patients were divided into group A and group B, each with 64 cases. Group A was treated with
atorvastatin, and group B used Puerarin injection. The two groups were compared in clinical efficacy, and the changes
of blood lipid, carotid atherosclerosis index. Results The effective rate was 98.4% in group B and 89.1% in group A,
with statistically significant difference between the two groups (P<0.05). After treatment in group B, total cholesterol
(TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high sensitivity C-reactive protein (hs-CRP) and
matrix metalloproteinase-9 (MMP-9) levels were significantly lower than group A, and the high-density lipoprotein
cholesterol (HDL-C) level was significantly increased (P<0.05). After treatment in group B, intima-media thickness
(IMT) and plaque area were lower than those in group A after treatment (P<0.05). Conclusion Compared with atorv-
astatin, Puerarin injection has better effect, which can suppress serum inflammatory factor more significantly, and dec-
arese blood lipid levels and reversing the carotid atherosclerosis.