标题：ODC和CD105在良性、癌前和恶性外阴肿瘤中的表达及意义

      作者：东 敏，刘建华，阮正一
    (上海交通大学附属第九人民医院妇科，上海 200010)

      卷次： 2015年26卷4期

      【摘要】 目的 探讨鸟氨酸脱梭酶(Ornithine decarboxylase，ODC)和 CD105蛋白(Cluster of differentiation
105，CD105)在外阴癌变中的作用。方法 选取30例外阴鳞癌、30例外阴上皮内瘤变和30例外阴正常表皮，采用
免疫组化的方法进行研究。分析ODC和CD105表达与外阴鳞癌的临床病理特征。结果 ODC和CD105在正常外
阴组织中的阳性率明显低于外阴上皮内瘤变组织和外阴鳞癌组织，而于外阴上皮内瘤变组织中的阳性率明显低
于外阴鳞癌组织，差异均有显著统计学意义(P<0.01)，ODC与细胞分化程度密切相关(P<0.05)，CD105与临床分期
和淋巴转移密切相关(P<0.05)。结论 ODC和CD105在外阴鳞癌发生和发展中具有重要的意义。

      【关键词】 鸟氨酸脱羧酶；CD105蛋白；外阴鳞癌；外阴上皮内瘤变

      【中图分类号】 R737.35 【文献标识码】 A 【文章编号】 1003—6350（2015）04—0481—03


Expression and significance of ODC and CD105 in benign, precancerous and malignant vulvar tumors.
DONG
Min, LIU Jian-hua, RUAN Zheng-yi. Department of Gynaecology, the Ninth People's Hospital Affiliated to Shanghai
Jiaotong University, Shanghai 200010, CHINA

【Abstract】 Objective To discuss the role of ornithine decarboxylase (ODC) and cluster of differentiation
105 (CD105) in vulvar tumor. Methods Thirty cases of malignant vulvar tumors, 30 cases of vulvar intraepithelial neo-
plasia, and 30 cases of normal vulvar tissue were studied by immunohistochemistry. ODC and CD105 expression and
clinical pathological features of vulvar squamous carcinoma were further analyzed. Results The positive expression
rate of ODC and CD105 in normal vulvar tissues was significantly lower than that in the genital intraepithelial neoplasia
and squamous cell carcinoma of the vulva, and the positive rate in vulvar intraepithelial neoplasia was significantly
lower than that in vulvar squamous cell carcinoma tissue, with statistically significant difference (P<0.01). ODC was
closely related to the degree of cell differentiation (P<0.05), and CD105 was closely related to clinical stage and lymph
node metastasis (P<0.05). Conclusion ODC and CD105 had vital significance in the development of vulvar squamous
carcinoma (HCC).

      【Key words】 Ornithine decarboxylase (ODC); Cluster of differentiation 105 (CD105); Vulvar squamous carcino-