标题：血FFA、Hcy和Cys-C测定在糖尿病肾病早期诊断中的应用价值

      作者：陈 薇 1，童秀峰 2，黎安玲 1，胡汉宁 1
    （1.武汉大学中南医院检验科，湖北 武汉 430071；
2.鄂州市梁子湖区医院检验科，湖北 鄂州 436060）

      卷次： 2015年26卷3期

      【摘要】 目的 研究游离脂肪酸(FFA)、同型半胱氨酸(Hcy)、胱抑素C (Cys-C)等指标血清水平与2型糖尿病
(T2DM)各阶段的关系以及应用价值。方法 选择T2DM患者150例，根据24 h尿微量白蛋白排泄率(UAER)分
为单纯糖尿病组(SDM组) 54例、早期糖尿病肾病期组(EDN组) 56例和临床糖尿病肾病期组(CDN组) 40例，同时
选择同期进行健康体检确定为健康者42例作为对照组。所有研究对象均测定血清中FFA、Hcy、Cys-C等指标含
量，采用方差分析和应用 Pearson相关性分析对各指标进行统计学分析。结果 CDN组、EDN组血清中 FFA、
Hcy、CysC水平均高于SDM组和对照组(P<0.05)，且血清中FFA、Hcy、CysC水平CDN组>EDN组>SDM组>对照
组，各组间比较差异均具有统计学意义(P<0.05)；T2DM患者血清 FFA、Hcy、CysC水平与UAER呈正相关(r=
0.718，0.417，0.361；P<0.05)。结论 糖尿病患者FFA、Hcy、CysC水平与糖尿病肾病的发展进程有关，各项指标
的联合检测对早期诊断糖尿病肾病有重要的临床应用价值。

      【关键词】 糖尿病肾病；游离脂肪酸；同型半胱氨酸；胱抑素C

      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2015）03—0375—03


Application value of serum FFA, Hcy and Cys-C levels in diagnosing diabetic nephropathy at early stage.
CHEN Wei 1, TONG Xiu-feng 2, LI An-ling 1, HU Han-ning 1.
1. Department of Clinical Laboratory, Zhongnan Hospital
of Wuhan University, Wuhan 430071, Hubei, CHINA; 2. Department of Clinical Laboratory, Liangzihu Hospital of Ezhou,
Ezhou 436060, Hubei, CHINA

【Abstract】 Objective To establish the relationship between indexes of serum free fatty acids (FFA), homo-
cysteine (Hcy) and Cystatin-C (Cys-C) levels with Type 2 diabetes mellitus (T2DM) at each stage, and to determine
their application values. Methods One hundred and fifty T2DM patients were selected and divided into three groups
according to the levels of urinary albumin excretion rates (UAER): simple diabetic mellitus group (SDM group, n=
54), early diabetic nephropathy group (EDN group, n=56), clinical diabetes nephropathy group (CDN group, n=40).
Forty-two healthy subjects of the same period determined by physical examination were enrolled as the control group.
FFA, Hcy and Cys-C and other indexes in serum were determined for all subjects. T-test and variance analysis and
Pearson correlation analysis were applied to make statistical analysis of all indexes. Results Serum FFA, Hcy, Cys C
levels in CDN group and EDN group were significantly higher than SDM group and the control group (P<0.05), and
the levels from high to low was CDN group, EDN group, SDM group, the control group, with statistically significant
difference between any two groups (P<0.05). In T2DM patients, the FFA, Hcy, Cys C levels were found positively cor-
related with UAER (r=0.718, 0.417, 0.361; P<0.05). Conclusion The FFA, Hcy and CysC levels of T2DM patients
are related with the development process of diabetic nephropathy. Joint detection of all indexes has significant clinical
application value in the early diagnosis of diabetic nephropathy.