标题：过敏性鼻炎患者主客观指标的相关性研究

      作者：陈光媚，杨桂梅，陈奕辉
    （海口市人民医院耳鼻咽喉科，海南 海口 570208）

      卷次： 2015年26卷3期

      【摘要】 目的 探讨儿童过敏性鼻炎患者的血清变应原特异性 lgE (slgE)水平、皮肤点刺试验(SPT）及外周
血嗜酸性粒细胞(EOS)计数、血清嗜酸粒细胞阳离子蛋白(ECP)、血清总 IgE (tlgE)与鼻部症状视觉模拟量表评分
(VAS)的相关性。方法 选取2013年1月至2014年4月在我科就诊的过敏性鼻炎儿童患者58例，采用VAS对患
者的病情严重度进行评价；应用国际标准方法做过敏原皮肤点刺试验，对所有病例检测外周血EOS计数，采用
UmCAPl00系统测定血清ECP、tlgE和 slgE水平；用Pearson相关分析对结果进行分析。结果 血清 sIgE和皮肤
点刺试验显著正相关(r=0.532，P<0.05)；EOS计数与血清 slgE之间具有显著相关性(r=0.3843，P<0.05)，而与皮
肤点刺实验阳性强度无显著相关性(r=0.182，P>0.05)。血清ECP水平与鼻塞症状VAS评分呈正相关(r=0.196，
P=0.022)，但与病情总体严重程度VAS评分无相关性(P>0.05)。血清 sIgE、SPT与鼻部症状VAS总分及EOS计数
均无明显相关性(P>0.05)。结论 皮肤点刺试验、血清 sIgE水平、血清总 IgE、外周血EOS计数与病情总体严重
程度VAS评分均未见相关性，但连续动态的血清 sIgE、皮肤点刺试验、ECP可作为症状体征评分的补充。

      【关键词】 过敏性鼻炎；症状评分；血清特异性 lgE；皮肤点刺试验

      【中图分类号】 R765.21 【文献标识码】 A 【文章编号】 1003—6350（2015）03—0366—03


Correlation of subjective and objective indicators in children with allergic rhinitis.
CHEN Guang-mei, YANG
Gui-mei, CHEN Yi-hui. Department of Otorhinolaryngology, Haikou People's Hospital, Haikou 570208, Hainan,
CHINA

【Abstract】 Objective To investigate the correlation of serum allergen-specific lgE (slgE) levels, skin prick
test (SPT) and peripheral blood eosinophils (EOS) count, serum eosinophil cationic protein (ECP), serum total IgE
(tlgE) with nasal symptoms visual analog scale score (VAS) in children with allergic rhinitis. Methods Fifty-eight
children of allergic rhinitis admitted in our department for January 2013 to April 2014 were enrolled. VAS was applied
to evaluate the severity of the patient's condition. International standard method was used to perform allergen skin
prick tests. All the patients were detected for peripheral blood EOS counts, as well as serum ECP, tlgE and slgE levels
by UmCAPl00 system. Pearson correlation analysis was applied to analyze the results. Results The serum sIgE and
skin prick tests showed a significant positive correlation (r=0.532, P<0.05). Peripheral blood eosinophils was signifi-
cantly correlated with serum sIgE (r=0.3843, P<0.05), but not with the positive strength of skin prick test (r=0.182, P>
0.05). Serum ECP levels were positively correlated with nasal symptoms VAS scores (r=0.196, P=0.022), but not with
the overall illness severity VAS score (P>0.05). There was no significant correlation between serum sIgE, SPT and na-
sal symptoms VAS score, peripheral blood eosinophil counts (P>0.05). Conclusion There is no correlation between
skin prick test, serum sIgE levels, serum total IgE, peripheral blood counts, and EOS overall severity of illness VAS
scores, but the continuous dynamic of serum sIgE, skin prick tests, ECP can be used as supplements for sign and symp-
tom score.

      【Key words】 Allergic rhinitis; Symptom score; Serum specific lgE; Skin prick test