标题：他克莫司联合窄谱中波紫外线治疗白癜风的临床效果及其影响因素分析

      作者：侯占英，刘 芳，黄 珍，刘万红
    (深圳市龙华新区中心医院皮肤科，广东 深圳 510110)

      卷次： 2015年26卷3期

      【摘要】 目的 探讨他克莫司软膏联合窄谱中波紫外线治疗白癜风的临床效果及其影响因素。方法 172
例白癜风患者随机分为观察组与对照组各86例，观察组给予他克莫司软膏联合窄谱中波紫外线治疗，对照组仅
给予窄谱中波紫外线照射治疗，对比两组患者的临床效果。根据治疗效果，分析性别、年龄、病程、病变类型、皮
损位置等因素对观察组患者疗效的影响。结果 观察组有效率为76.7% (66/86)，显著高于对照组的52.3% (45/86)
(P<0.01)；不同年龄、皮损部位、病程以及病变类型患者有效率比较差异均有统计学意义(P<0.05或P<0.01)，而不
同性别患者有效率比较差异无统计学意义(P>0.05)。结论 他克莫司软膏联合窄谱中波紫外线照射能够快速、有
效的恢复白癜风患者患处肤色、缩小皮损面积，但患者年龄、病程、皮损位置、病变类型等因素对疗效影响较大。

      【关键词】 他克莫司；窄谱中波紫外线；白癜风；因素

      【中图分类号】 R758.4+1 【文献标识码】 A 【文章编号】 1003—6350（2015）03—0363—03


Clinical effects and influence factors of tacrolimus combined with narrow band ultraviolet B in patients with
vitiligo.
HOU Zhan-ying, LIU Fang, HUANG Zhen, LIU Wan-hong. Department of Dermatology, Longhua New District
Central Hospital, Shenzhen 510110, Guangdong, CHINA

【Abstract】 Objective To discuss the clinical effects and influence factors of tacrolimus combined with
(NB-UVB) in patients with vitiligo. Methods A total of 172 patients with vitiligo were randomly divided into the ob-
servation group (n=86) and the control group (n=86). The observation group were treated with tacrolimus combined
with NB-UVB, while the control group were treated with NB-UVB only. Clinical effects were contrasted between the
two groups. Then gender, age, course of disease, pathological type, vitiligo patches were analyzed according to the
clinical effects to discuss the influence to the clinical effects. Results The effective rate of the observation group was
76.7% (66/86), significantly higher than 52.3% (45/86) in the control group (P<0.01). There were statistically significant
differences in age, vitiligo patches, course of disease and pathological type in effective rates (P<0.05 or P<0.01), but
there was no statistically significant difference in patients' gender (P>0.05). Conclusion Tacrolimus ointment com-
bined with NB-UVB can rapidly, effectively recover skin color and shrink lesion area in patient's with vitiligo, but pa-
tient's age, course of disease, lesion location, pathological type and other factors would influence the curative effect to a
large extent.