标题：复方苦参腔内灌注治疗对恶性胸腔积液患者胸水中VEGF、MMP含量的影响

      作者：张振安，安 静，张风林，袁亚军
    (唐山市人民医院唐山市肿瘤医院呼吸科，河北 唐山 063000)

      卷次： 2015年26卷2期

      【摘要】 目的 探讨复方苦参腔内灌注治疗对恶性胸腔积液患者胸水中VEGF、MMP含量的影响。方法 选
择在本院接受住院治疗的恶性胸腔积液患者作为研究对象，随机分为接受常规胸腔内化疗的对照组及接受复方苦
参腔内灌注治疗的观察组，比较两组患者的治疗后胸水VEGF、MMP含量及T细胞亚群分布差异。结果 (1)观察组
患者接受治疗后的VEGFA、VEGFB、VEGFC水平均显著低于对照组患者(P<0.05)；(2)观察组患者接受治疗后的
胸水MMP-2及MMP-9含量均显著低于对照组患者(P<0.05)；(3)观察组患者接受治疗后的CD3+、CD4+、CD4+/CD8+
水平均明显高于对照组患者(P<0.05)。结论 复方苦参腔内灌注治疗可以明显降低患者胸水VEGF、MMP含量，
优化机体免疫功能。

      【关键词】 恶性胸腔积液；复方苦参；VEGF；MMP

      【中图分类号】 R655 【文献标识码】 A 【文章编号】 1003—6350（2015）02—0166—03


Effect of compound matrine intracavity perfusion on VEGF, MMP levels in hydrothorax in patients of
malignant pleural effusion.
ZHANG Zhen-an, AN Jing, ZHANG Feng-lin, YUAN Ya-jun. Department of Respiratory
Medicine, Tangshan People's Hospital, Tangshan Cancer Hospital, Tangshan 063000, Hebei, CHINA

【Abstract】 Objective To analyze the effect of compound matrine intracavity perfusion on vascular endothe-
lial growth factor (VEGF), matrix metalloproteinase (MMP) levels in hydrothorax in patients of malignant pleural effu-
sion. Methods Patients with malignant pleural effusion in our hospital were selected as research objects, which were
randomly divided into control group with conventional intrathoracic chemotherapy and observation group with com-
pound matrine intracavity perfusion. VEGF, MMP levels and T cell subgroup distribution were compared between the two
groups after treatment. Results (1) VEGFA, VEGFB, VEGFC levels after treatment in observation group were signifi-
cantly lower than those in the control group (P<0.05). (2) The levels of MMP-2 and MMP-9 after treatment in observation
group were significantly lower than those in control group (P<0.05). (3) The levels of CD3+, CD4+, CD4+/CD8+ after treat-
ment in observation group were significantly higher than those in control group (P<0.05). Conclusion Compound ma-
trine intracavity perfusion could significantly decrease VEGF, MMP content in hydrothorax in patients of malignant
pleural effusion, and optimize body's immune function.

      【Key words】 Malignant pleural effusion; Compound matrine; Vascular endothelial growth factor (VEGF); Ma-
trix metalloproteinase (MMP)
基金项目：河北省中医药学会资助项目(编号：20132106)