标题：消化性溃疡与血型、幽门螺杆菌感染和Lewis表型分布的相关性研究

      作者：罗 艳，王瑞彤
    （航天中心医院感染性疾病科，北京 100039）

      卷次： 2015年26卷1期

      【摘要】 目的 探讨消化性溃疡与ABO血型、幽门螺杆菌感染及Lewis表型分布的关系。方法 选取我院
2010年1月至2013年12月收治的75例消化性溃疡患者作为观察组，75例健康成年人作为对照组，分析两组研究
对象的门螺杆菌感染、ABO血型以及Lewis表型分布差异。结果 ①观察组患者中Le(a+b+)患者共 26例，占
34.67%；对照察组患者中Le(a+b+)患者共8例，占10.67%，两者比较差异具有显著统计学意义(P<0.01)；②观察组
患者中不同ABO血型中幽门螺杆菌的感染率(A型57.14%，B型50.00%，O型52.78%，AB型57.14%)之间比较差
异均无统计学意义(P>0.05)；观察组患者中 Lewis表型为 Le(a-b+)的患者感染率为 71.79%，明显高于其他
Lewis表型，差异具有显著统计学意义(P<0.01)。结论 消化性溃疡与幽门螺杆菌感染以及Lewis表型分布均
有一定的关系，Lewis表型为Le(a+b+)的人群消化性溃疡发病风险较大，Lewis表型为Le(a-b+)可能是门螺杆菌
感染的高危因素。

      【关键词】 消化性溃疡；门螺杆菌；Lewis表型

      【中图分类号】 R573.1 【文献标识码】 A 【文章编号】 1003—6350（2015）01—0022—03


Correlation of peptic ulcer with blood type, Helicobacter pylori infection, and Lewis phenotype distribution.
LUO Yan, WANG Rui-tong.
Department of Infectious Diseases, Space Center Hospital, Beijing 100039, CHINA

【Abstract】 Objective To analyze the correlation of peptic ulcer with ABO blood type, Helicobacter pylori in-
fection, and Lewis phenotype distribution. Methods Seventy-five patients with peptic ulcer were selected as the ob-
servation group and 75 health adults were enrolled as the control group (with hospitalized time limited from January
2010 to December 2013). The differences of subjects' pylori infection, ABO blood type and Lewis phenotype distribu-
tion between the two groups were analyzed. Results ① There were 26 Le (a+b+) cases in the observation group (ac-
counting for 34.67%), with only 8 in the control group (10.67%), and the difference was statistically significant (P<
0.01); ② In the observation group, the Helicobacter pylori infection rate between patients with different ABO blood
type (type A 57.14%, type B 50%, type O 52.78%, type AB 57.14%) showed no statistically significant difference (P>
0.05); the infection rate of Le (a-b+) patients was 71.79%, which was significantly higher than that of other Lewis phe-
notype, and the difference was statistically significant (P<0.01). Conclusion There is a certain correlation between
peptic ulcer, Helicobacter pylori infection and Lewis phenotype distribution. People with Le (a+b+) Lewis phenotype
may be at higher risk of peptic ulcer, and people with Le (a-b+) may be at higher risk of Helicobacter pylori infection.

      【Key words】 Peptic ulcer; Helicobacter pylori; Lewis phenotype
基金项目：首都卫生发展科研立项项目（编号：首发2011-4023-01）