标题：经颅直流电刺激对急性脑梗死患者血清Hcy及hs-CRP的影响

      作者：李正宇，张盘德，陈惠琼，周惠嫦
    (佛山市第一人民医院康复科，广东 佛山 528000)

      卷次： 2016年27卷11期

      【摘要】 目的 探讨经颅直流电刺激(tDCS)对急性脑梗死患者血清同型半胱氨酸(Hcy)和高敏C反应蛋白
(hc-CRP)水平的影响。方法 按照随机、对照方法将佛山市第一人民医院康复科在 2013年 2月至 2014年 11月收
治的 106例急性脑梗死住院患者分为两组(n=53)，对照组患者实施常规药物治疗，并应用促通技术进行康复治
疗，观察组在此基础上加用经颅直流电刺激疗法，比较两组患者治疗前后的血清Hcy、hs-CRP水平变化，并应用
FMA (运动功能评分)和Barthel指数(BI)评估治疗效果。结果 观察组患者治疗后的Hcy、hs-CRP水平分别为
(11.41±1.15) μmol/L、(9.32±1.87) mg/L，均明显低于对照组的(16.65±4.33) μmol/L、(12.36±1.85) mg/L，组间比较差异
均有统计学意义(P<0.05)；观察组患者治疗后的FMA、BI评分分别为(66.7±24.6)分、(70.5±12.8)分，均明显高于对照
组的(53.8±22.6)分、(47.2±12.3)分，组间比较差异均有统计学意义(P<0.05)。结论 经颅直流电刺激治疗急性脑梗
死能有效降低血清Hcy、hs-CRP水平，促进肢体运动功能恢复，提高治疗效果。

      【关键词】 急性脑梗死；经颅直流电刺激；高敏C反应蛋白；同型半胱氨酸

      【中图分类号】 R743.33 【文献标识码】 A 【文章编号】 1003—6350（2016）11—1770—03


Effect of transcranial direct current stimulation on serum Hcy and hs-CRP in patients with acute cerebral
infarction.
LI Zheng-yu, ZHANG Pan-de, CHEN Hui-qiong, ZHOU Hui-chang. Department of Rehabilitation, the First
People's Hospital of Foshan, Foshan 528000, Guangdong, CHINA

【Abstract】 Objective To investigate effect of the transcranial direct current stimulation (tDCS) on the level of
the serum homocysteine (Hcy) and high-sensitive C reactive protein (hc-CRP) in patients with acute cerebral infarction.
Methods A total of 106 patients with acute cerebral infarction in Department of Rehabilitation in the First People's Hospi-
tal of Foshan from February 2013 to November 2014 were selected. The patients were divided into the control group (n=53)
and the observation group (n=53) according to the random number table. The patients in control group only received routine
drug therapy, and the rehabilitation therapy was carried out by using facilitation technique. The observation group was treat-
ed with transcranial direct current stimulation on the basis of the control group. The serum levels of Hcy and hs-CRP were
compared between the two groups before and after treatment. FMA (motor function score) and Barthel index (BI) were
used to evaluate the therapeutic effect. Results After treatment, the levels of Hcy and hs-CRP in the observation group
were significantly lower than those in control group [(11.41±1.15) μmol/L vs (16.65±4.33) μmol/L, (9.32±1.87) mg/L vs
(12.36±1.85) mg/L, P<0.05]. After treatment, FMA, BI scores in the observation group were significantly higher than those
in control group [(66.7±24.6) vs (53.8±22.6), (70.5±12.8) vs (47.2±12.3), P<0.05]. Conclusion Transcranial direct cur-
rent stimulation in the treatment of acute cerebral infarction can effectively reduce serum Hcy and hs-CRP levels, pro-
mote the recovery of limb function, and improve the therapeutic effect.

      【Key words】 Acute cerebral infarction; Transcranial direct current stimulation; High-sensitive C reactive protein
(hs-CRP); Homocysteine (Hcy)
·论 著·
6350.2016.11.015