标题：抗血小板药物对阻塞型睡眠呼吸暂停综合征合并不稳定性心绞痛患者血小板功能的影响

      作者：刘焕波，吴歆华，林忠婕，孙鹏，刘娟，李泽
    (中国人民解放军第425医院心血管内科，海南 三亚 572000）

      卷次： 2016年27卷11期

      【摘要】 目的 探讨抗血小板药物阿司匹林及氯吡格雷对阻塞型睡眠呼吸暂停综合征（OSAS）合并不稳定性
心绞痛(UAP)患者血小板功能的影响。方法 选取2013年1月至2015年12月在我科住院治疗的118例UAP患者，
根据有无OSAS分为UAP合并OSAS组46例与单纯UAP组72例，检测两组患者血小板数量、平均体积、分布宽度，
以及阿司匹林、氯吡格雷双联抗血小板治疗前后的血小板聚集率。结果 (1) OSAS合并UAP组与单纯UAP组患
者的血小板计数[(164.1±63.4) vs (191.2±63.0)]比较，差异无统计学意义(P>0.05)，但血小板平均体积[(12.78±1.58) vs
(8.97±1.11)]和血小板分布宽度[(13.51±1.68) vs (9.08 ±1.35)]比较，差异均有统计学意义(P<0.05)；(2)双联抗血小板
治疗前，OSAS合并UAP组血小板聚集率为(77.5±5.9)%，明显高于单纯UAP组的(60.1±5.4)%，差异有统计学意义
(P<0.05)。经抗血小板治疗后，两组血小板聚集率均较治疗前下降[(50.6±5.9)%，(33.3±5.6)%]，但OSAS合并UAP
组仍高于单纯UAP组，差异有统计学意义(P<0.05)。结论 OSAS合并UAP患者血小板聚集性增高，双联抗血小板
治疗后血小板聚集性均下降，但不能完全抵消OSAS对血小板聚集性的影响。

      【关键词】 不稳定性心绞痛；阻塞型睡眠呼吸暂停综合征；抗血小板药物

      【中图分类号】 R541.4 【文献标识码】 A 【文章编号】 1003—6350（2016）11—1752—04


Effect of anti-platelet drugs on platelet function in patients with obstructive sleep apnea syndrome complicated
with unstable angina.
LIU Huan-bo, WU Xin-hua, LIN Zhong-jie, SUN Peng, LIU Juan, LI Ze. Department of
Cardiology, the 425th Hospital of People's Liberation Army, Sanya 572000, Hainan, CHINA

【Abstract】 Objective To investigate the effect of aspirin and clopidogrel on platelet function in patients with
obstructive sleep apnea syndrome (OSAS) complicated with unstable angina pectoris (UAP). Methods A total of 118
patients with UAP in our hospital were selected from January 2013 to December 2015. According to whether the patients
had OSAS or not, they were divided into UAP combined with OSAS group (UAP & OSAS group, n=46) and simple
UAP group (n=72). The platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and the platelet
aggregation rate before and after anti-platelet therapy with aspirin and clopidogrel were detected. Results (1) There
were no significant difference in terms of the platelet count between the two groups [(164.1±63.4) vs (191.2±63.0), P>
0.05], but MPV and PDW had statistically significant difference between the two groups [(12.78±1.58) vs (8.97±1.11),
(13.51±1.68) vs (9.08±1.35), P<0.05]. (2) Before dual anti-platelet therapy, the platelet aggregation rate in the UAP &
·论 著·
6350.2016.11.009