标题：2型糖尿病肾病患者血清同型半胱氨酸、脂蛋白(α)和胱抑素C测定结果分析

      作者：胡 伟，胡孝彬，陈 江，郭 渝
    (宜宾市第二人民医院检验科，四川 宜宾 644000)

      卷次： 2014年25卷20期

      【摘要】 目的 探讨血清同型半胱氨酸(Hcy)、脂蛋白(α)[Lp(α)]和胱抑素C (Cys-C)水平变化在2型糖尿病
肾病(Type 2 diabetic nephropath，T2DN)诊断中的临床应用价值。方法 在日立7600-020全自动生化分析仪上测
定 106例T2DN患者(实验组)和 92例健康者（对照组）的血清Hcy、Lp(α)、Cys-C和糖化血红蛋白(HbA1c)，并对测
定结果进行比较分析。结果 实验组患者的Hcy、Lp(α)、Cys-C和HbA1c水平显著高于对照组(P<0.05)；早期糖尿
病肾病组和中晚期糖尿病肾病组Hcy、Lp(α)、Cys-C和HbA1c水平均高于单纯糖尿病组(P<0.05)；中晚期糖尿病
肾病组Hcy、Lp(α)、Cys-C和HbA1c水平高于早期糖尿病肾病组(P<0.05)。结论 血清Hcy、Lp(α)和Cys-C可作
为T2DN早期肾损伤较为理想的评价指标，能为T2DN早期诊断、病情监测和疾病预后等方面提供有价值的实
验依据。

      【关键词】 2型糖尿病肾病；同型半胱氨酸；脂蛋白(α)；胱抑素C

      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2014）20—3009—03


Clinical value of serum homocysteine, lipoprotein (α) and cystatin C in type 2 diabetic nephropathy.
HU Wei,
HU Xiao-bin, CHEN Jiang, GUO Yu. Department of Clinical Laboratory, the Second People's Hospital of Yibin, Yibin
644000, Sichuan, CHINA

【Abstract】 Objective To study the diagnostic value of serum homocysteine (Hcy), lipoprotein (α) [Lp (α)]
and Cystatin C (Cys-C) testing in type 2 diabetic nephropathy (T2DN). Methods The serum levels of Hcy, Lp(α),
Cys-C and glycosylated hemoglobin (HbA1c) in 106 cases of T2DN (experimental group) and 92 healthy subjects (con-
trol group) were determined by 7600-020 automatic biochemical analyzer and the results were compared. Results In
the experimental group, the levels of Hcy, Lp(α), Cys-C and HbA1c were significantly higher than those in the control
group (P<0.05); the levels of Hcy, Lp(α), Cys-C and HbA1c in early or advanced diabetic nephropathy group were sig-
nificantly higher than those in simple diabetic group (P<0.05); and the levels of Hcy, Lp(α), Cys-C and HbA1c in ad-
vanced diabetic nephropathy group were significantly higher than those in the early diabetic nephropathy group (P<
0.05). Conclusion The serum Hcy, Lp(α) and Cys-C can be regarded as optimal indexes to evaluate early renal inju-
ry in T2DN, which can provide experimental data for monitoring and its prognosis.