标题：巴戟天多糖对去卵巢大鼠骨质疏松症的防治作用

      作者：刘亦恒 1，吴多庆 1，朱振标 1，黄 重 1，陈晓虹 1，张海英 2
    (1.海口市人民医院骨科中心，海南 海口 570208；
2.海南医学院人体解剖学教研室，海南 海口 571101)

      卷次： 2014年25卷20期

      【摘要】 目的 观察巴戟天多糖对去卵巢大鼠骨质疏松症的影响。方法 成年雌性SD大鼠30只，随机分
为假手术组、模型组、巴戟天多糖组，每组10只。采用摘取双侧卵巢法建立骨质疏松模型，造模2周后开始给药，
给药3个月后观察巴戟多糖天对大鼠骨密度、骨矿物质含量、血清雌二醇、骨钙素及1，25-二羟基维生素D3的影
响。结果 给药3个月后，与模型组比较，巴戟天多糖组能显著提高去卵巢大鼠的骨密度、骨矿物质、1，25-二羟
基维生素D及骨钙素的含量。结论 巴戟天多糖对去卵巢所致的大鼠骨质疏松症具有良好的防治作用。

      【关键词】 骨质疏松；去卵巢大鼠；巴戟天多糖

      【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350（2014）20—2973—03


Protective and therapeutic effects of morindae officinails polysaccharides on osteoporosis of ovariectomized
rats.
LIU Yi-heng 1, WU Duo-qing 1, ZHU Zhen-biao 1, HUANG Zhong 1, CHEN Xiao-hong 1, ZHANG Hai-ying 2. 1.
Depantment of Orthopaedics, Haikou Municipal People's Hospital, Haikou 570208, Hainan, CHINA; 2. Department of
Anatomy, Hainan Medical College, Haikou 571101, Hainan, CHINA

【Abstract】 Objective To observe the protective and therapeutic effects of morindae officinails polysaccha-
rides on osteoporosis of ovariectomized rats. Methods Thirty adult female SD rats were divided randomly into
sham-operated group, model group, morindae officinails polysaccharides group. Every group had ten rats. We extract-
ed bilateral ovaries to establish osteoporosis model, which were treated with medicine two weeks postoperationally for
consecutively 3 months. Then we observed the protective and therapeutic effects of morindae officinails polysaccha-
rides on rat bone mineral density (BMD), bone mineral content, estrogen, osteocalcin, 1, 25-dihydroxyvitamin D3.
Results After 3 months, the morindae officinails polysaccharides group could significantly improve the BMD, bone
mineral content, osteocalcin, 1, 25-dihydroxyvitamin D3 of the ovariectomized rats, compared with model group.
Conclusion Morindae officinails polysaccharides can antagonize osteoporosis of the ovariectomized rats.

      【Key words】 Osteoporosis; Ovariectomized rats; Morindae officinails polysaccharides