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      标题:TGF-β调控自噬活性研究进展
      作者:王雅雯 综述,徐 普 审校
    (中南大学湘雅医学院附属海口医院口腔医学中心,海南 海口 570208)
      卷次: 2014年25卷18期
      【摘要】 自噬是细胞成分更新、发育、分化的重要调控机制,对维持蛋白代谢平衡及细胞内环境稳定具有重
要意义。TGF-β是一种具有多种功能的多肽生长因子,可促进细胞的增殖与分化,细胞的粘附、迁移和凋亡,参
与了自噬活性的调控。

      【关键词】 自噬;TGF-β;自噬基因;自噬信号通路

      【中图分类号】 R329.2+5 【文献标识码】 A 【文章编号】 1003—6350(2014)18—2715—03


Review of the regulation of TGF-β in autophagic activity.

WANG Ya-wen, XU Pu. Stomatology Center, Haikou
Hospital Affiliated to XiangYa Medicine School, Central South University, Haikou 570208, Hannan, CHINA
【Abstract】 Autophagy is regarded as an important pathway for renewal development and differentiation
among eukaryotic cells, which plays a key role in maintaining protein metabolism and homeostasis. As a multifunc-
tional polypeptide growth factor, TGF-β not only stimulates cell proliferation and differentiation, cell adhesion,
spreading and apoptosis, but also participates in the regulation of autophagic activity.

      【Key words】 Autophagy; TGF-β; Autophagy gene; Autophagy signaling pathway

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