标题：生物蛋白胶宫颈封堵术在未足月胎膜早破中的临床应用

      作者：李小瑜，傅 斌，黎月仪
    (广州市白云区第一人民医院妇产科，广东 广州 510410)

      卷次： 2014年25卷14期

      【摘要】 目的 探讨生物蛋白胶宫颈封堵术治疗未足月胎膜早破的有效性。方法 将在我院治疗的28例
未足月胎膜早破孕产妇随机分为三组，A组10例采用B超监测下经宫颈插管生物蛋白胶封堵法治疗，B组8例行
腔镜介导下宫颈插管推注生物蛋白胶封堵术，C组10例行羊膜镜介导下宫颈插管推注生物蛋白胶封堵胎膜破口
术，三组再给予相同的抑制宫缩治疗和护理，比较三组孕产妇的手术效果和分娩差异。结果 A组孕产妇治愈0
例(0.0%)，有效 2例(20.0%)，无效 8例(80.0%)，其中自然分娩 2例，人工助产 3例，剖宫产 5例，胎儿存活率为
60.0%；B组孕产妇治愈2例(25.0%)，有效4例(50.0%)，无效2例(25.0%)，其中自然分娩4例，人工助产1例，剖宫产
3例，胎儿存活率为83.3%；C组孕产妇治愈8例(80.0%)，有效1例(10.0%)，无效1例(10.0%)，其中自然分娩8例，人
工助产1例，剖宫产1例，胎儿存活率为100.0%，治疗效果和术后分娩情况显著优于其他两组，其差异均具有统计
学意义(P<0.05)。结论 羊膜镜介导下生物蛋白胶封堵胎膜破口法结合了传统方法的优点，封堵成功率高，操作
相对简单，而且不需要注水，不影响生物蛋白胶的凝固，值得推广。

      【关键词】 生物蛋白胶；宫颈封堵术；未足月胎膜早破

      【中图分类号】 R714.43+3 【文献标识码】 A 【文章编号】 1003—6350（2014）14—2051—03


Application of biological fibrin glue closure in pregnant women with preterm premature rupture of membrane.
LI Xiao-yu, FU Bin, LI Yue-yi.
Department of Obstetrics and Gynecology, the First People's Hospital of Baiyun District of
Guangzhou, Guangzhou 510410, Guangdong, CHINA

【Abstract】 Objective To investigate the effectiveness of biological fibrin glue closure in pregnant women
with preterm premature rupture of membrane. Methods Twenty-eight cases of pregnant women with preterm prema-
ture rupture of membrane from March 2012 to December 2013 in our hospital were selected and divided into three
groups randomly. All three groups were treated with biological fibrin glue closure via the cervical intubation with the
monitoring of ultrasound (Group A, 10 cases), endoscopy (Group B, 8 cases) and amnioscopy (Group C, 10 cases). To-
colytics were applied as following in all groups. And then the effectiveness and differences in delivery were compared.
Results In Group A, the cure rate, effective rate and inefficiency rate were 0.0% (0 case), 20.0% (2 cases) and 80.0%
(8 cases) respectively, with 2 cases of natural childbirth, 3 cases of operative vaginal delivery and 5 cases of cesarean
section, and the fetal survival rate was 60.0% . In Group B, the cure rate, effective rate and inefficiency rate were