标题：结肠癌组织中Cofilin-1蛋白的表达及临床病理意义

      作者：刘 艳 1，林建姣 1，胡红松 1，刘荣火 1，章任兵 2
    (深圳市龙岗区人民医院消化内科 1、病理科 2，广东 深圳 518172)

      卷次： 2015年26卷21期

      【摘要】 目的 探讨结肠癌组织中Cofilin-1蛋白的表达及其与肿瘤侵袭和转移的关系。方法 应用免疫
组织化学SP法检测60例结肠癌组织、40例癌旁正常组织、26例转移淋巴结组织标本中Cofilin-1蛋白的表达水
平，并结合临床病理参数进行分析。结果 Cofilin-1蛋白在结肠癌组织、转移淋巴结组织中表达率分别为
76.7%、61.5%，均明显高于癌旁正常组织中的32.5%表达率。Cofilin-1在结肠癌组织、转移淋巴结组织中的表达
率明显高于癌旁正常组织，差异均有统计学意义(P<0.05)；Cofilin-1蛋白的表达水平与结肠癌组织分化程度、
Dukes分期、浆膜侵犯及淋巴结转移有关 (P<0.05)，而与性别、年龄、肿瘤大小无明显相关(P>0.05)；Cofilin-1与结
肠癌预后密切相关(P<0.05)。结论 检测 Cofilin-1蛋白的表达有助于判断结肠癌的浸润、转移及预后。

      【关键词】 丝切蛋白-1；结肠癌；转移; 预后

      【中图分类号】 R735.3+5 【文献标识码】 A 【文章编号】 1003—6350（2015）21—3130—03


Expression and clinicopathological significance of Cofilin-1 protein in colonic cancer.
LIU Yan 1, LIN Jian-jiao 1,
HU Hong-song 1, LIU Rong-huo 1, Zhang Ren-bing 2. Department of Gastroenterology 1, Department of Pathology 2,
Longgang District People's Hospital of Shenzhen, Shenzhen 518172, Guangdong, CHINA

【Abstract】 Objective To investigate the expression of Cofilin-1 protein and its clinicopathological signifi-
cance in colonic cancer. Methods The expression of Cofilin-1 protein in 60 colonic cancer specimens, 40 adjacent
normal tissues, 26 lymph node metastasis tissues was detected by SP method. Meanwhile, the relationship between the
expression of Cofilin-1 and the clinical pathologic factors was analyzed. Results The positive rate of Cofilin-1 expres-
sion was 76.7% in colonic cancer specimens, 61.5% in lymph node metastasis tissues, which were significantly higher
than 32.5% in adjacent normal tissues (P<0.05). Positive expression of Cofilin-1 protein was significantly associated
with histology grading, Dukes stage, serosal invasion and lymph node metastasis (P<0.05), but not with gender, age and
the size of tutor (P>0.05). Cofilin-1 was closely related to the prognosis of colonic cancer (P<0.05). Conclusion The
detection of Cofilin-1 protein can help judge the invasion, metastasis and prognosis of colonic cancer.

      【Key words】 Cofilin-1 protein; Colonic cancer; Metastasis; Prognosis