标题：他汀类药物对慢性阻塞性肺疾病患者治疗作用的Meta分析

      作者：赵考昌，陈国忠
    （武汉大学人民医院呼吸内科，湖北 武汉 430060）

      卷次： 2015年26卷2期

      【摘要】 目的 系统评价他汀类药物对慢性阻塞性肺疾病(COPD)患者的治疗作用。方法 计算机检索
PubMed、维普(VIP)、万方数据库、中国知网和中国生物医学文献数据库(CBM)中关于他汀类药物对慢性阻塞性
肺疾病患者治疗作用的随机对照试验，检索时限为建库至2014年4月。由研究者根据GRADE系统推荐分级方
法，对纳入文献进行质量评价，对符合质量标准的文献采用Review Manager 5.1和GRADEprofiler 3.6软件进行
Meta分析。结果 共纳入12篇研究，Meta分析结果显示：他汀类药物对慢性阻塞性肺疾病患者FEV1%预计值和
FEV1/FVC的改善作用与对照组比较差异有统计学意义[WMD=3.30，95%CI (1.25，5.35)，P=0.002；WMD=4.05，
95%CI (2.52，5.58)，P<0.000 01]；同时与对照组比较，他汀类药物可显著降低慢性阻塞性肺疾病患者C反应蛋白
(CRP)水平，差异有统计学意义[WMD=-1.19，95%CI (-1.67，-0.71)，P<0.000 01]。结论 现有研究显示他汀类药
物可显著改善慢性阻塞性肺疾病患者肺功能并降低其全身炎症反应，值得在临床上推广。

      【关键词】 慢性阻塞性肺疾病；他汀类药物；系统评价；Meta分析

      【中图分类号】 R563 【文献标识码】 A 【文章编号】 1003—6350（2015）02—0272—05


Meta-analysis: effect of statins in the treatment of patients with chronic obstructive pulmonary disease.
ZHAO
Kao-chang, CHEN Guo-zhong. Department of Respiratory Medicine, People's Hospital of Wuhan University, Wuhan
430060, Hubei, CHINA

【Abstract】 Objective To evaluate the effect of statins in the treatment of patients with chronic obstructive
pulmonary disease (COPD) systematically. Methods PubMed, Wanfang Data, VIP Data, CNKI and CBM were
searched for researches of Randomized controlled trials (RCTs) on statins in the treatment of patients with chronic ob-
structive pulmonary disease, with time limited from the databases' establishment dates to April 2014. The included re-
searches were evaluated based on the GRADE system, then meta-analysis on the qualified researches were performed
by adopting Review Manager 5.1 and GRADE profiler 3.6. Results The meta-analysis of all twelve researches
showed that the difference of predicted FEV1% and FEV1/FVC between the two groups was statistically significant
[WMD=3.30, 95%CI (1.25, 5.35), P=0.002; WMD=4.05, 95%CI (2.52, 5.58), P<0.000 01]; Meanwhile, by comparing
with the control group, patients in the treatment group showed an obvious lower C-reactive protein (CRP) level
[WMD=-1.19, 95%CI (-1.67, -0.71), P<0.000 01]. Conclusion The current evidence showed that statins can signifi-
cantly improve lung function and systemic inflammatory responses in COPD patients, and is thus worthy of application.

      【Key words】 Chronic obstructive pulmonary disease; Statins; Systematic review; Meta-analysis
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