标题：肺炎支原体感染患儿血清总胆汁酸水平探讨

      作者：黄远真，陈金兰，黄永攀，曾华，李泽臻
    (南宁市第一人民医院检验科，广西 南宁 530028)

      卷次： 2016年27卷10期

      【摘要】 目的 分析肺炎支原体感染患儿血清总胆汁酸(TBA)水平变化，探讨血清TBA检测的临床意义。
方法 选取2015年4~8月我院儿科接收的100例肺炎支原体感染患儿(观察组)及同期进行健康体检的100例非肺
炎支原体感染儿童(对照组)作为研究对象，入院当天检测观察组血清TBA水平，并与对照组比较。根据病情轻重
将观察组分为轻度组(n=48)、中度组(n=35)、重度组(n=17)，比较其血清TBA水平差异。根据血清TBA水将观察组
分为两组，≤10 μmol/L组(32例)及>10 μmol/L组(68例)，对两组患者的临床资料进行回顾性分析，采用单因素及
logistic回归多因素分析影响肺炎支原体感染患儿血清TBA变化的相关因素。结果 观察组患者的血清TBA水平
为(17.5±6.04) μmol/L，对照组为(4.41±1.65) μmol/L，观察组高于对照组，差异有统计学意义(P<0.05)。肺炎支原体
感染轻度组血清TBA检测结果为(6.52±3.63) μmol/L，中度组为(16.6±4.88) μmol/L，重度组为(29.8±10.7) μmol/L，肺
炎支原体感染患儿随着病情的加重，其血清TBA水平呈现进行性升高（P<0.05）；单因素及Logistic多因素分析提
示：年龄、体重指数、谷丙转氨酶(ALT)、谷草转氨酶(AST)是肺炎支原体感染患儿血清TBA水平>10 μmol/L的危险
因素(P<0.05)。结论 对肺炎支原体感染患儿血清TBA实施动态监测有助于评估患者的肝损伤及疾病严重程度，
对改善预后有重要价值。

      【关键词】 肺炎支原体感染；总胆汁酸；动态监测；危险因素

      【中图分类号】 R725.6 【文献标识码】 A 【文章编号】 1003—6350（2016）10—1587—03


Clinical significance of serum total bile acid levels in children with mycoplasma pneumoniae infection.
HUANG
Yuan-zhen, CHEN Jin-lan, HUANG Yong-pan, ZENG Hua, LI Ze-zhen. Department of Clinical Laboratory, the First
People's Hospital of Nanning, Nanning 530028, Guangxi, CHINA

【Abstract】 Objective To explore the clinical significance of serum total bile acid (TBA) levels detection
through analyzing the serum total bile acid levels in children with mycoplasma pneumoniae infection. Methods A total
of 100 cases of children with mycoplasma pneumoniae infection, who enrolled in Department of Pediatrics of our hospi-
tal from April 2015 to August 2015, were selected as the observation group. Another 100 cases of children with no pneu-
monia mycoplasma infection, who enrolled in our hospital for physical examination during the same period, were chosen
as a control group. On the day of admission, serum TBA levels of observation group and control group were detected
and compared. According to the condition of mycoplasma pneumoniae infection, the observation group was divided into
mild group (n=48), moderate group (n=35) and severe group (n=17), and the serum levels of three subgroups were com-
pared. According to the levels of TBA, the observation group was divided into two groups,≤10 μmol/L group (32 cases)
and >10 μmol/L group (68 cases), and the clinical data of two groups were retrospectively analyzed through single factor
and multi-factor logistic regression analysis. Results The serum TBA level of observation group [(17.5 ± 6.04) μmol/L]
was significantly higher than that of control group [(4.41±1.65) μmol/L] (t=8.064, P<0.05). With the deterioration of myco-
plasma pneumoniae infection, the serum TBA level was significantly increased [mild TBA group with (6.52 ±3.63) μmol/L,
moderate group with (16.6±4.88) μmol/L, severe group (29.8 ±10.7) μmol/L, P<0.05]. Univariate and multivariate logis-
tic analysis indicated that age, body mass index, valley pyruvic transaminase and aspartate aminotransferase were risk
factors for serum TBA level>10 μmol/L (P<0.05). Conclusion Dynamic monitoring of serum TBA level in children
with mycoplasma pneumoniae infection can be helpful to assess liver injury and the status of disease, which has an im-
portant value for prognosis.

      【Key words】 Pneumonia mycoplasma infection; Total bile acid (TBA); Dynamic monitoring; Risk factors
·论 著·
6350.2016.10.013