标题：3 169例孕中期孕妇产前筛查结果分析

      作者：王 婷 1，张 涛 1，王军阳 2，刘 静 3，杨 亮 1，舒柳亮 1
    (1.安康市中心医院核医学科，陕西 安康 725000；
2.西安交通大学医学院免疫系，陕西 西安 710061；
3.安康市中心医院检验科，陕西 安康 725000)

      卷次： 2014年25卷13期

      【摘要】 目的 分析安康地区孕中期孕妇产前唐氏综合征、18-三体综合征和神经管缺陷的筛查结果。
方法 选取2011年12月至2013年5月安康地区的3 169例孕中期孕妇为研究对象，将其唐氏综合征、18-三体综
合征、神经管缺陷高危风险比例进行统计分析，并比较其中不同年龄与孕周者的高危风险比例。结果 3 169例
孕中期孕妇中共检出唐氏综合征高风险者96例(3.03%)，18-三体综合征高风险者30例(0.95%)，神经管缺陷高风
险者32例(1.01%)，其中≤20岁及≥35岁者的总比例均高于其他年龄段，其差异均有统计学意义(P<0.05)，而不同
孕周者之间则差异无统计学意义(P>0.05)。结论 安康地区孕中期孕妇以唐氏综合征高风险比例高于18-三体
综合征和神经管缺陷，且不同年龄段的差异也较为明显。

      【关键词】 安康地区；孕中期；唐氏综合征；神经管缺陷；18-三体综合征；产前筛查

      【中图分类号】 R714.15 【文献标识码】 A 【文章编号】 1003—6350（2014）13—1934—02


Analysis of screening results to 3 169 women at second trimester pregnancy.
WANG Ting 1, ZHANG Tao 1,WANG
Jun-yang 2, LIU Jing 3, YANG Liang 1, SHU Liu-liang 1. 1. Department of Nuclear Medicine, Central Hospital of Ankang
City, Ankang 725000, Shaanxi, CHINA; 2. Department of Immunology, Xi'an Jiaotong University Health Science Center,
Xi'an 710061, Shaanxi, CHINA; 3. Department of Clinical Laboratory, Central Hospital of Ankang City, Ankang 725000,
Shaanxi, CHINA

【Abstract】 Objective To analyze the prenatal screening results of Down syndrome (DS), Edwards syndrom
and neural tube defect (NTD) in mid-pregnant women at Ankang area. Methods A total of 3 169 pregnant women with
mid-trimester pregnancy at Ankang prefecture from December 2011 to May 2013 were selected as research object, and
the high risk proportion of DS, Edwards syndrome and NTD were statistically analyzed, then the high risk proportion of
pregnant women with different ages and gestational weeks were compared too. Results 158 cases of 3 169 pregnant
women with mid-trimester pregnancy were classified as the high risk group, from which 96 (3.03%), 30 (0.95%) and 32
(1.01%) babies were born with disease of DS, Edwards syndrome and NTD, respectively. The high risk rates of pregnant
women were quite different among age groups with the highest in≤20 years old and≥35 years old，the rates of the two
age stages (≤20 years old and≥35 years old) were significantly different (all P<0.05) from the rates of other age stages.
The high risk rates of pregnant women among different gestational weeks showed no significant differences (all P>0.05).
Conclusion The high risk rate of DS of pregnant women with mid-trimester pregnancy in Ankang area were higher than
the rates of Edwards syndrom and NTD, and the difference among different gestational weeks were significant.

      【Key words】 Ankang area; Mid-trimester pregnancy; Down's syndrome; Neural tube defect; Edwards syn-
drom; Prenatal screening