标题：改良化学性迷路切除治疗单侧顽固性梅尼埃病的临床研究

      作者：林金超，庄黎明，张 肖，吴首乌，吴烽芳，蔡耿明，林伟年
    (福建医科大学附属泉州市第一医院耳鼻咽喉科，福建 泉州 362000）

      卷次： 2014年25卷13期

      【摘要】 目的 观察采用经鼓室内注入含庆大霉素明胶海绵泥浆进行化学性迷路切除治疗单侧顽固性梅
尼埃病的临床疗效。方法 对20例诊断为单侧顽固性梅尼埃病的患者通过鼓室内注入含庆大霉素明胶海绵泥浆
进行化学性迷路切除（观察组），同时选取20例单侧顽固性梅尼埃病药物保守治疗患者作为临床对照（对照组）。观
察两组患者治疗后眩晕发作、耳鸣情况、听力变化、生活工作能力恢复情况及并发症。结果 观察组经过化学性迷
路切除后，20例中有14例眩晕情况得到完全控制，控制率为75.0%。对照组中仅有3例眩晕情况得到完全控制，控
制率为15.0%，两组比较差异有统计学意义(P<0.01)。此外，观察组患者耳鸣情况、听力变化、生活工作能力恢复情
况等均优于对照组(P<0.01)。结论 化学性迷路切除治疗单侧顽固性梅尼埃病疗效稳定确切，安全可靠。

      【关键词】 化学性迷路切除；庆大霉素；顽固性梅尼埃病

      【中图分类号】 R764.33 【文献标识码】 A 【文章编号】 1003—6350（2014）13—1931—03


Clinical study on modified chemical labyrinthectomy in the treatment of intractable Meniere's disease.
LIN
Jin-chao, ZHUANG Li-ming, ZHANG Xiao, WU Shou-wu, WU Feng-fang, CAI Geng-ming, LIN Wei-nian. Department of
Otorhinolaryngology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, Fujian, CHINA

【Abstract】 Objective To observe the clinical curative effect of chemical labyrinthectomy in the treatment of
intractable Meniere's disease by injecting gentamicin gelatin sponge mud into intratympanic. Methods Twenty patients
with unilateral intractable Meniere's disease were treated with intratympanic injection of gelatin sponge mud soaked in
gentamicin (observation group), and the other 20 with unilateral intractable Meniere's disease were given conservative
treatment for (control group). The onset of vertigo, tinnitus, hearing change, life and work ability recovery and complica-
tions were observed in two groups after treatment. Results In the observation group, 14 patients with vertigo was com-
pletely controlled after chemical labyrinthectomy and the control rate was 75%. In the control group, only 3 patients with
vertigo was completely controlled, and the control rate was 15%. There was a significant difference between the two
groups (P<0.01). In addition, the improvement of tinnitus, hearing change, life and work ability recovery and complica-
tions in the observation group were significantly bigger than those in the control group (P<0.01). Conclusion Chemi-
cal treatment in unilateral labyrinthectomy intractable Meniere's disease is effective, stable, safe and reliable.