标题：独一味水提物对大鼠血液凝集参数的影响

      作者：廖应琼 1，邓治国 1，韦会平 2
    (1.攀钢集团总医院药剂科，四川 攀枝花 617023；
2.攀枝花学院医学院，四川 攀枝花 617023)

      卷次： 2014年25卷11期

      【摘要】 目的 研究藏药独一味对凝血作用和血液凝集参数的影响。方法 以云南白药(0.09 g/kg)为阳性
对照组，蒸馏水为空白对照组，独一味水提物为试验组，试验组分高(0.3 g/kg)、中(0.15 g/kg)、低(0.075 g/kg)三个剂
量组，给大鼠灌胃给药14 d后，颈总动脉采血测定其凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶
时间(TT)以及纤维蛋白原含量(FIB)。结果 与空白对照组比较，独一味水提物的高、中、低剂量组及云南白药组
的TT值分别缩短了 25.77%、12.42%、8.60%和 24.91%；FIB值分别增加了 26.80%、6.38%、20.72%和 9.44%；PT、
APTT值无明显变化。结论 独一味水提物能增加大鼠纤维蛋白原的含量并能缩短大鼠凝血酶时间。

      【关键词】 独一味；水提物；止血；凝血酶时间；纤维蛋白原

      【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350（2014）11—1561—03


Effect of Herba Lamiophlomis rotata on blood coagulation parameters of rats.
LIAO Ying-qiong 1, DENG
Zhi-guo 1, WEI Hui-ping 2. 1. Pharmaceutical Preparation Section，Hospital of Panzhihua Metal Group, Panzhihua
617023, Sichuan, CHINA; 2. Medical School, Panzhihua University, Panzhihua 617023, Sichuan, CHINA

【Abstract】 Objective To study the effect of tibet medicine herba lamiophlomis rotata on blood coag-
ulation parameters (PT, APTT, TT) of rats. Methods Yunnan Baiyao powder (0.09 g/kg), distilled water,
high dose (0.3 g/kg), middle dose (0.15 g/kg), low dose (0.075 g/kg) of the aqueous extract of L. rotata, were taken
orally by rats for fourteen days. Blood samples were culled from common carotid artery and PT, APTT, TT and FIB of
these samples were determined. Results Compared to the blank control group, the reduced rates of TT values of the
high, middle and low dose groups and Yunnan Baiyao powder group were 25.77%, 12.42%, 8.60% and 24.91%, re-
spectively. The increased rates of FIB values were 26.80%, 6.38%, 20.72% and 9.44%, respectively. There were no ob-
vious changes in PT and APTT values between all groups. Conclusion The aqueous extract of L. rotata could in-
crease the content of FIB and shorten TT value.

      【Key words】 Lamiophlomis rotata; Aqueous extract; Hemostatic; TT; FIB
·论 著·