标题:健脾益肺口服液对慢阻肺“肺脾气虚证”大鼠脾脏指数和胸腺指数的影响
作者:何 嘉,郭建辉,梁 栋,史肃育
(南京市中医院呼吸科,江苏 南京 210001)
卷次:
2014年25卷10期
【摘要】 目的 观察健脾益肺口服液对慢阻肺“肺脾气虚证”大鼠脾脏指数、胸腺指数的影响。方法 将
65只SD成年雄性大鼠随机分为 6组,分别为空白组,健脾益肺口服液高、中、低剂量组,模型组,地塞米松组。
用香烟熏吸和脂多糖(LPS)复制慢阻肺“肺气虚”模型;接着用大黄液灌胃,复制“脾气虚证”;造模共为 28 d,在
造模开始 14 d开始给药,28 d麻醉后取血处死后剥离大鼠脾脏及胸腺,计算脾脏指数、胸腺指数。结果 (1)模
型组大鼠体重、脾脏指数、胸腺指数低于空白组(P<0.05或P<0.01);(2)健脾益肺口服液各治疗组大鼠体重、脾指
数、胸腺指数显著增加,与模型组比较差异有统计学意义(P<0.05),其中高剂量组与模型组比较,差异有显著统计
学意义(P<0.01);(3)高、中、低剂量三组组间大鼠体重、脾脏指数、胸腺指数比较差异均无统计学意义(P>0.05)。
结论 健脾益肺口服液可提升慢阻肺大鼠体重,而脾脏指数、胸腺指数相应提高,从而使机体免疫力得到提高,机
体防病抗病力得到加强。
【关键词】 健脾益肺口服液;慢性阻塞性肺疾病;肺脾气虚证;脾脏指数;胸腺指数
【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350(2014)10—1412—03
Influence of spleen-strengthening and lung-tonifying liquid on spleen index and thymus index of COPD in rats
with Lung and spleen qi deficiency syndrome.
HE Jia, GUO Jian-hui, LIANG Dong, SHI Su-yu. Department of
Respiratory Medicine, Nanjing Hospital of Traditional Chinese Medicine, Nanjing 210001, Jiangsu, CHINA.
【Abstract】 Objective To observe the effect of spleen-strengthening and lung-tonifying liquid on thymus in-
dex and spleen index of COPD in rats with lung-spleen qi deficiency syndrome. Methods Sixty-five adult SD male
rats were randomly divided into six groups, normal control group, 3 spleen-strengthening and lung-tonifying liquid
groups with small, middle or large dosage separately, model group and dexamethasone control group. Rats was treated
with smoke and LPS, and followed by rhubarb liquid through gavaging, to generate model of lung-qi deficiency. Mod-
el-making lasted for 28 days. Rats were given medicine on day 14 of model-making. 28 days later, blood was taken af-
ter anesthesia, and then the spleen index and thymus index was calculated after the spleen and thymus were peeled
from rats. Results (1) The weight, spleen index and thymus index of model group were significantly lower than
those of normal control group (P<0.05 or P<0.01). (2) The weight, thymus index and spleen index in all
spleen-strengthening and lung-tonifying liquid groups increased,especially the large dose group, which were higher
than those in the normal control group (P<0.05 or P<0.01). (3) There were no striking changes in thymus index and
spleen index in large dose, middle dose and small dose treatment groups (P>0.05). Conclusion Spleen-strengthening
and lung-tonifying liquid can increase body weight, spleen index and thymus index of the rats with COPD, and then
improve body immunity and disease resistance.
【Key words】 Spleen-strengthening and lung-supplementing liquids; Chronic obstructive pulmonary disease
(COPD); Lung-spleen qi deficiency syndrome; Spleen index; Thymus index
基金项目:南京市卫生局课题(编号:YKK11042)
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