标题：1 126例尿路感染的病原菌分布及药物敏感性分析

      作者：龙小平，李玉梅
    （自贡市第四人民医院检验科，四川 自贡 643000）

      卷次： 2014年25卷8期

      【摘要】 目的 了解本院近年尿路感染的病原菌分布及药物敏感情况，为临床合理用药提供依据。
方法 对我院 2010年 8月至 2013年 4月分离出的 1 125株病原菌的分布情况进行统计，并对常见的致病菌
株进行药物敏感性分析。 结果 尿路感染以大肠埃希菌检出率最高，为 52.80%，其后依次为肠球菌属
(13.07%)、克雷伯菌属(7.02%)、铜绿假单胞菌(4.62%)。大肠埃希菌和肺炎克雷伯菌ESBLs检出率分别为45.1%
和34.5%。分离的病原菌中排列前四位的革兰氏阴性杆菌对亚胺培南最敏感，对阿米卡星、哌拉西林/他唑巴坦
也有较高敏感性。排列前四位的革兰氏阳性球菌对万古霉素敏感性为100%。结论 大肠埃希菌仍为尿路感染
最常见的病原菌，病原菌菌谱分布广，敏感的药物较少，多重耐药严重。临床应该高度重视标本的送检及根据药
敏报告合理使用抗生素，不滥用抗生素，减少耐药株的产生。

      【关键词】 尿路感染；病原菌；敏感性

      【中图分类号】 R691.3 【文献标识码】 B 【文章编号】 1003—6350（2014）08—1221—03


Distribution and antibiotics susceptibility analysis of pathogens in 1 119 cases of urinary tract infection.
LONG
Xiao-ping, LI Yu-mei. Department of Laboratory Medicine, the Fourth People’s Hospital of Zigong City, Zigong 643000,
Sichun, CHINA

【Abstract】 Objective To analyze the distribution and antibiotics susceptibility of pathogens in urinary
tract infection and provide experience to reasonable clinical usage of antibacterials. Methods The distribution
and antibiotic susceptibility of 1 119 pathogens collected in our hospital from January 2010 to August 2012 were
analyzed. Results Escherichia coli was the most prodominant pathogen with a percentage of 52.73%, followed by
Enterococcus (13.05% ), Klebsiella (7.06% ) and Pseudomonas aeruginosa (4.65% ). The incidence of ESBLs in was
45.1% in E. coli and 34.5% in Klebsiella pneumoniae. The most sensitive antibiotics to the first grade of four species
of gram-negative was carbopenems, and the most sensitive antibiotics to the first grade of four species of gram-posi-
tive was vancomyin (100%). Conclusion E. coli is the most predominant pathogen of urinary tract infection, with wide dis-
tribution, less sensitive antibiotics, and severe multidrug resistance. The clinical staffs should pay more attention to the test of the
samples and the reasonable use of antibiotics with drug susceptibility for decreasing the resistant strains.