标题：血管内皮生长因子研究进展及其与胰腺癌的相关研究

      作者：杨小秋，谈 顺
    (中南大学湘雅医学院附属海口医院病理科，海南 海口 570208)

      卷次： 2014年25卷8期

      【摘要】 在胰腺癌的生长和转移中新生血管形成（Angiogenesis）是其从小结节进展成为具有侵袭能力重要
的一步。血管内皮生长因子是肿瘤血管新生过程中最重要的驱动因子，血管新生的主要调节者。随着VEGF途
径作用机制研究的日益深入，VEGF与胰腺癌的关系也受到越来越多的关注。本文从VEGF的结构和功能、调控
因素及相关调控机制，VEGF在胰腺癌中表达的临床意义，以及抗VEGF治疗在胰腺癌中的相关研究进展方面，
对VEGF在胰腺癌中的研究现状做一介绍。

      【关键词】 血管内皮生长因子；胰腺癌；抗VEGF治疗

      【中图分类号】 R735.9 【文献标识码】 A 【文章编号】 1003—6350（2014）08—1157—04


Research progress of vascular endothelial growth factor in pancreatic carcinoma.
YANG Xiao-qiu, TAN Shun.
Department of Pathology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou
570208, Hainan, CHINA
【Abstract】 In the growth and metastasis process of pancreatic carcinoma, angiogenesis is a vital step which makes
the tumor have the ability of metastasis from a small nodule. Vascular endothelial growth factor (VEGF) is viewed as a cru-
cial driving factor and the major regulator in the process of angiogenesis. With the deepening research of the mechanism of
VEGF pathway, studies on VEGF and pancreatic cancer have become a focusing topic. Therefore, the relationship between
VEGF and pancreatic carcinoma is reviewed in this article. Then, we summarized the recent findings from the following as-
pects: the characteristics of VEGF (including the structure and function, modulating factors and regulation mechanism), the
clinical significance of VEGF and anti-VEGF therapy in pancreatic carcinoma.