标题：中国汉族人群Ghrelin基因Leu72Met多态性与2型糖尿病相关性Meta分析

      作者：崔兆辉 1，宋瑞娟 2，胡长军 1，陆卫平 1
    （南京医科大学附属淮安第一医院内分泌科 1、医保处 2，江苏 淮安 223300）

      卷次： 2014年25卷7期

      【摘要】 目的 探讨ghrelin基因Leu72Met (C408A)位点多态性与中国汉族2型糖尿病（T2DM）人群发病的
关系。方法 检索中国生物医学文献数据库、万方医学网，检索时间范围包括2013年5月之前的所有文献，分别
检索到研究ghrelin基因Leu72Met位点多态性与中国汉族T2DM相关文献15篇。按纳入、排除标准选取病例，采
用RevMan4.2.10分析其相关性。结果 纳入研究文献5篇（涉及 l 132例2型糖尿病患者和961名对照组)。Meta
分析结果表明，中国汉族人群2型糖尿病与Leu72Met位点多态性相关：AA基因型与CA基因型和CC基因型合
并后比较，固定效应模型 OR=2.55，95% CI：1.07~6.11，P=0.03 ；AA基因型与CC基因型比较，固定效应模型
OR=2.63，95% CI：1.09~6.30，P=0.03；等位基因A与C比较，固定效应模型 OR=1.30，95% CI：1.06~1.60，P=0.01。
结论 Ghrelin基因Leu72Met位点多态性与中国汉族人群2型糖尿病的发生发展可能有关。

      【关键词】 2型糖尿病；Ghrelin基因；Leu72Met；基因多态性；Meta分析

      【中图分类号】 R587.1 【文献标识码】 A 【文章编号】 1003—6350（2014）07—1053—04


Relationship between ghrelin Leu72Met polymorphism and type 2 diabetes mellitus among the Chinese Han
population: a meta-analysis.
CUI Zhao-hui 1, SONG Rui-juan 2, HU Chang-jun 1, LU Wei-ping 1. Department of
Endocrinology 1, Health Insurance Office 2, Huai'an First People's Hospital Affiliated to Nanjing Medical University,
Huai'an 223300, Jiangsu, CHINA

【Abstract】 Objective To evaluate the relationship between ghrelin Leu72Met polymorphism and type 2 dia-
betes mellitus (T2DM) among the Chinese Han population. Methods We conducted a computer retrieval of
SINOMED, Wanfang databases prior to May 2013. Articles investigating the relationship of T2DM and ghrelin
Leu72Met polymorphism of Han group were found through literature. According to the including and excluding crite-
ria, a meta-anatysis was performed in T2DM and ghrelin Leu72Met polymorphism, including 15 articles on Leu72Met
polymorphism and T2DM. The association was examined by RevMan4.2.10 software. Results Five articles on
Leu72Met polymorphism were include (involving l 132 cases of T2DM and 961 controls). Meta-analysis showed that
there was a significant association between Leu72Met polymorphism and T2DM: AA/(CA+CC) (fixed-effect model,
OR=2.55, 95% CI: 1.07~6.11, P=0.03). AA/CC (fixed-effect model, OR=2.63, 95% CI: 1.09~6.30, P=0.03). A/C al-
lele comparison (fixed-effect model, OR=1.30, 95% CI: 1.06~1.60, P=0.01). Conclusion Ghrelin Leu72Met poly-
morphism may be related with development of type 2 diabetes mellitus in the Chinese Han population.

      【Key words】 Type 2 diabetes mellitus (T2DM); Ghrelin genotype; Leu72Met; Gene polymorphism; Meta-analysis
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