标题：原发性肝癌腹水患者肾功能早期损害标志物的评价及意义

      作者：钟文洲 1，郑秀芳 1，李春芸 2
    （海口市人民医院消化内科 1、检验科 2，海南 海口 570208）

      卷次： 2014年25卷5期

      【摘要】 目的 探讨原发性肝癌腹水患者肾功能早期损害标志物的评价及意义。方法 选择我院收治的
150例原发性肝癌患者，根据是否并发腹水分为肝癌组 53例，肝癌腹水组 97例，同期健康体检者 38例作为
正常对照组，检测静脉血和尿标本中的肾功能标志物。结果 肝癌腹水组和肝癌组血清Cys C、IgG、mAlb、
α1-M、β2-MG及SCr水平均明显高于对照组(P<0.05)；肝癌腹水组血清Cys C、IgG、mAlb、α1-M及SCr水平均明显
高于肝癌组(P<0.05)；肝癌组和肝癌腹水组Child-Pugh等级为B、C级的血清Cys C、IgG、mAlb、α1-M及β2-MG水
平均明显高于A级(P<0.05)；肝癌腹水组Child-Pugh等级为C级的血清Cys C、IgG、mAlb、α1-M、β2-MG、SCr及
Urea水平均明显高于B级(P<0.05)。结论 血清Cys C、IgG、mAlb、α1-M及β2-MG水平随着肝癌患者病情进展和
肾功能损害而升高，比传统的血清SCr、Urea更敏感地反映肝癌腹水患者肾功能早期损害。

      【关键词】 原发性肝癌；肾功能；标志物

      【中图分类号】 R735.7 【文献标识码】 A 【文章编号】 1003—6350（2014）05—0682—03


Evaluation and significance of early markers of renal function damage in primary liver cancer patients with
ascites.
ZHONG Wen-zhou 1, ZHENG Xiu-fang 1, LI Chun-yun 2. Department of Gastroenterology 1, Department of
Clinical Laboratory 2, People's Hospital of Haikou City, Haikou 570208, Hainan, CHINA

【Abstract】 Objective To investigate the evaluation and significance of early markers of renal function dam-
age in primary liver cancer patients with ascites. Methods One hundred and fifty patients with primary liver cancer
in our hospital were selected, and divided into liver cancer group (n=53) and liver cancer ascites group (n=97) accord-
ing to whether they were complicated with ascites. Thirty-eight healthy individuals over the same period were selected
as the control group. Markers of renal function in blood and urine specimens were tested. Results The levels of Cys
C, IgG, mAlb, α 1-M, β 2-MG and SCr in liver cancer group and liver cancer ascites group were significantly higher
than those in the control group (P<0.05); the levels of Cys C, IgG, mAlb, α1-M and SCr in liver cancer ascites group
were significantly higher than liver cancer group (P<0.05); Cys C, IgG, mAlb, α1-M and β2-MG in liver cancer group
and liver cancer ascites group of Child-Pugh B, C were significantly higher than Child-Pugh A (P<0.05); Cys C, IgG,
mAlb, α 1-M, β 2-MG, SCr and Urea in liver cancer ascites group of Child-Pugh C were significantly higher than
Child-Pugh B (P<0.05). Conclusion Cys C, IgG, mAlb, α1-M and β2-MG levels increase with the progression of liv-
er cancer and renal dysfunction, which are more sensitive to reflect the renal function damage in primary liver cancer
patients with ascites than the traditional serum SCr, Urea.

      【Key words】 Primary liver cancer; Renal function; Markers
·论 著·