标题：CYP2C19基因多态性指导消化溃疡质子泵抑制剂及抗Hp治疗的价值

      作者：刘 英 综述，黄晓曦 审校
    （中南大学湘雅医学院附属海口医院海口市人民医院消化内科，海南 海口 570208）

      卷次： 2014年25卷3期

      【摘要】 质子泵抑制剂（PPI）已成为消化性溃疡的重要药物，既有利于溃疡创面的愈合，又可以为抗生素根
除幽门螺杆菌提供适合的酸性环境。随着对 CYP2C19基因多态性研究的不断深入，近期一些研究表明
CYP2C19基因多态性对消化性溃疡质子泵抑制剂及幽门螺杆菌治疗的疗效有着重要的影响，本文就CYP2C19
基因多态性指导消化溃疡质子泵抑制剂及抗Hp治疗的价值做简要综述。

      【关键词】 CYP2C19基因多态性；消化性溃疡；质子泵抑制剂；幽门螺杆菌

      【中图分类号】 R975 【文献标识码】 A 【文章编号】 1003—6350（2014）03—0372—04


Value of CYP2C19 genetic polymorphism to guide proton pump inhibitors in the treatment of digestive ulcer
and Helicobacter pylori.
LIU Ying, HUANG Xiao-xi. Department of Gastroenterology, Haikou People's Hospital, the
Affiliated Hospital of Xiangya School of Medicine of Central South University, Haikou 570208, Hainan, CHINA
【Abstract】 Proton pump inhibitors (PPI) has become the important drugs to treat peptic ulcer, which can pro-
mote the healing of ulcer wound, and can offer acidic environments for antibiotics eradicate Helicobacter pylori (HP).
Along with the deepening research of the CYP2C19 genetic polymorphism, some studies have recently shown that
CYP2C19 gene polymorphisms have the important influence for the curative effect of proton pump inhibitors in the
treatment of peptic ulcer and HP therapy. In this paper, the value of CYP2C19 genetic polymorphism to guide proton
pump inhibitors in the treatmentof digestive ulcer and HP is reviewed.

      【Key words】 CYP2C19 gene; Polymorphisms; Pepticulcer Proton pump inhibitors (PPI); Helicobacter pylori (HP)
·综 述·