标题：多发性内分泌腺瘤ⅡA型的超声表现

      作者：陈 雷，丁 炎，吴鹏西
    (南京医科大学附属无锡人民医院超声医学科，江苏 无锡 214023)

      卷次： 2014年25卷3期

      【摘要】 目的 探讨多发性内分泌腺瘤ⅡA型的超声表现，提高对该病的认识和诊断水平。方法 回顾性
分析经临床手术病理证实的11例患者的超声及临床资料。结果 11例患者分属4个家系，尿3-甲氧-4羟基杏
仁酸(VMA)均升高。甲状腺髓样癌发病均早于肾上腺嗜铬细胞瘤，超声声像图示：病灶多侵及甲状腺双叶(8/11)，
以低回声为主(15/19)，并伴有钙化灶(18/19)，其中粗大钙化灶居多(12/18)，边界多见不规则声晕(11/19)，病灶血流
多为Ⅲ级(15/19)。伴颈部淋巴结转移者8例(8/11)；病理示其中有5例(5/11)合并甲状旁腺增生，超声确诊其中4
例。肾上腺嗜铬细胞瘤定位诊断符合率为90.90% (20/22)，定性诊断符合率为90% (18/20)。结论 超声对该病
的定位定性诊断具有重要价值，可作为对该病家族成员随访的首选影像学检查方法。

      【关键词】 多发性内分泌腺瘤ⅡA型；超声检查；病灶

      【中图分类号】 R730.261 【文献标识码】 A 【文章编号】 1003—6350（2014）03—0361—03


Ultrasonic appearance of multiple endocrine neoplasia type ⅡA.
CHEN Lei, DING Yan, WU Peng-xi. Department
of Medical Ultrasound, Wuxi People's Hospital Affiliated to Nanjing Medical College, Wuxi 214023, Jiangsu, CHINA

【Abstract】 Objective To explore the ultrasonographic findings of the multiple endocrine neoplasia typeⅡA
and to improve the understanding and diagnostic level of this disease. Methods We retrospectively analyzed the ul-
trasonographic findings and clinical data of 11 patients of the multiple endocrine neoplasia typeⅡA confirmed by pa-
thology. Results All 11 patients belonging to four families showed raised urinary 3-methoxy-4 hydroxy vanilly-
mandelic acid (VMA) levels. The onset of medullary thyroid carcinoma was earlier than adrenal pheochromocyto-
ma. The ultrasonographic findings were as follows: lesion invades bilateral lobes of thyroid (8/11), mainly with hy-
poecho (15/19), accompanied by calcifications (18/19), the majority of which were bulky calcifications (12/18), ir-
regular border acoustic halo mostly (11/19), lesion blood flow of grade Ⅲ (15/19). 8 cases had cervical lymph node
metastasis (8/11). 5 cases (5/11) combined with parathyroid hyperplasia, in which 4 cases were diagnosed by the ul-
trasound. The coincidence rate of localization and qualitative diagnosis of adrenal pheochromocytoma was 90.90%
(20/22) and 90% (18/20) respectively. Conclusion Ultrasound has important value on the localization and qualita-
tive diagnosis of this disease, and is the first choice of the follow-up imaging examination for members of this dis-
ease family.