标题：成年男性同型半胱氨酸与性激素水平的相关性研究

      作者：施德毅 1，梁振家 1，黄 章 1，陈永东 1，莫曾南 2,3，张幼捷 2，谢远亮 2，谭爱花 3，高 勇 3，严芝光 4
    （1.防城港市第一人民医院心血管内科，广西 防城港 538000；
2.广西医科大学第一附属医院泌尿外科，广西 南宁 530021；
3.广西医科大学基因组与个体化医学研究中心，广西 南宁 530021；
4.防城港市第一人民医院检验科，广西 防城港 538000）

      卷次： 2014年25卷3期

      【摘要】 目的 探讨成年男性血清同型半胱氨酸（Hcy）与性激素水平的关系。方法 对2009年9~12月在
防城港市第一人民医院体检中心进行健康体检的1 922名成年男性进行横断面调查。分别采用电化学发光免疫
法、循环酶法测定血清性激素与Hcy水平。以多元线性回归分析Hcy与各性激素水平的相关关系。结果 年龄、
卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）及内生肌酐清除率（Ccr）在不同Hcy水平组中分布差异存在统
计学意义（P值分别为0.001、0.001、0.002、0.007及0.001）。在多元线性回归模型中，校正年龄、BMI、Ccr、吸烟、
饮酒及体力活动后，血清Hcy与E2呈正相关性（β=0.083，95%CI：0.039~0.127），而与FSH、LH、T及SHBG无相关
性。结论 在健康成年男性中，空腹血清Hcy水平与E2独立相关。

      【关键词】 男性；同型半胱氨酸；性激素

      【中图分类号】 R446.6 【文献标识码】 A 【文章编号】 1003—6350（2014）03—0323—04


Relationship of serum homocysteine with sex hormone in males.
SHI De-yi 1, LIANG Zhen-jia 1, HUANG Zhang 1,
CHEN Yong-dong 1, MO Zeng-nan 2,3, ZHANG You-jie 2, XIE Yuan-liang 2, TAN Ai-hua 3, GAO Yong 3, YAN
Zhi-guang 4. 1. Department of Cardiovascular Medicine, Fangchenggang First People's Hospital, Fangchenggang
538000, Guangxi, CHINA; 2. Department of Urology and Nephrology, the First Affiliated Hospital of Guangxi Medical
University, Nanning 530021, Guangxi, CHINA; 3. Center for Genomic and Personalized Medicine, Guangxi Medical
University, Nanning 530021, Guangxi, CHINA; 4. Department of Clinical Laboratory, Fangchenggang First People's
Hospital, Fangchenggang 538000, Guangxi, CHINA

【Abstract】 Objective To explore the relationship between serum homocysteine (Hcy) and sex hormone in
adult males. Methods A total of 1 922 men aged 20 to 69 years who participated in the population-based Fangcheng-
gang Area Male Health and Examination Survey (FAMHES), which was carried out in Guangxi province of China
from September 2009 to December 2009, were assessed in this cross-section study. Serum sex hormone was measured
with electrochemiluminescence immunoassay. Multiple linear regression analysis was performed to analyze the associ-
ations between Hcy and sex hormones. Results Factors as age, the levels of follicle-stimulating hormone (FSH), lu-
teinizing hormone (LH), estradiol (E2) and endogenous creatinine clearance rate (Ccr) differed significantly in four
groups of different Hcy levels (P=0.001, P=0.001, P=0.002, P=0.007 and P=0.001, respectively). In multiple linear re-
gression models, after adjustment for age, BMI, Ccr, smoking, drinking, and physical activity, serum Hcy had posi-
tive correlation with E2 (β=0.083, 95% CI: 0.039~0.127), but had no relationships with FSH, LH, T, and SHBG.
Conclusion In healthy males in Fangchenggang, E2 levels are independently associated with the Hcy levels.