标题：甲状腺内胸腺或鰓囊相关肿瘤临床病理观察

      作者：解 娜 1，黄幼生 1，薛逢贵 1，陈恩斌 2，高 白 1
    (1.海南医学院附属医院病理科，海南 海口 570102；
2.武警海南省边防总队医院，海南 海口 570208)

      卷次： 2014年25卷2期

      【摘要】 目的 探讨甲状腺内胸腺或鰓囊相关肿瘤的临床病理特点及诊断思路。方法 对甲状腺内胸腺
或鰓囊相关肿瘤2例进行常规临床病理分析及免疫组织化学标记，并复习相关文献。结果 甲状腺的胸腺或鰓
囊相关肿瘤相对罕见，包括异位胸腺瘤(例1)、伴胸腺样分化的梭形细胞肿瘤(例2)和显示胸腺样分化的癌。肿瘤
有相对清晰的边界和分叶状结构，不同程度的梭形瘤细胞增生，免疫标记显示CK19阳性、TG阴性为其共同特
征。结论 甲状腺内胸腺或鰓囊相关肿瘤的形态及生物学行为与其具体病理类型相关，结合免疫组化标记可与
其他梭形细胞肿瘤鉴别，特别是与甲状腺髓样癌、未分化癌、滑膜肉瘤等鉴别。

      【关键词】 甲状腺；异位胸腺瘤；伴胸腺样分化的梭形细胞肿瘤；临床病理学；鉴别诊断

      【中图分类号】 R736.1 【文献标识码】 A 【文章编号】 1003—6350（2014）02—0277—04


Clinicopathologic observation of tumors in the thyroid showing thymic or related branchial pouch
differentiation.
XIE Na 1, HUANG You-sheng 1, XUE Feng-gui 1,CHEN En-bin 2, Gao Bai. 1. Deparntment of
Pathology, the Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan, CHINA; 2. Armed Police
Frontier Hospital of Hainan Province. Haikou 570208, Hainan, CHINA

【Abstract】 Objective To analyze the clinicopathologic characteristics, diagnosis, treatment and prognosis of
tumors in the thyroid showing thymic or related branchial pouch differentiation. Methods Two cases of tumors in
the thyroid showing thymic or related branchial pouch differentiation were analyzed by observation of the clinicopath-
ological features and the immunohistochemical study, and related literatures were reviewed. Results The relative
rare tumors in the thyroid showing thymic or related branchial pouch differentiation were included ectopic thymomas
(case 1), spindle epithelial tumor with thymus-like differentiation (SETTLE，case 2) and carcinoma showing thy-
mus-like differentiation (CASTLE). This family of tumors was Characterized by relative clear boundary, lobulated，
CK19 positive spindle-cell arranged in intersecting, but TG negative. Conclusion Tumors of the thyroid showing
thymic or related branchial pouch differentiation spans a range of histologic appearances and behaviors from complete-
ly benign lesions to metastasizing malignant tumors, and the prognosis is determined by its pathologic classification.
The immunohistochemical results may aid in making the correct differential diagnosis with other spindle cell tumors,
especially to be distinguishing from undifferentiated carcinoma, medullary carcinoma and synovial sarcoma.

      【Key words】 Thyroid；Ectopic Thymoma; SETTLE；Clinicopathology；Differential diagnosis
·临床病理·