标题：57例维吾尔族糖尿病合并肾病的临床与病理

      作者：杨淑芬，张 玲，何 卫，岳 华
    （新疆维吾尔自治区人民医院肾病科，新疆 乌鲁木齐 830001）

      卷次： 2014年25卷1期

      【摘要】 目的 分析新疆维吾尔族糖尿病合并肾病的临床与病理特点。方法 收集2003年1月至2012年
12月我院57例维吾尔族2型糖尿病患者肾活检资料，根据肾活检结果对单纯糖尿病肾病(DN)组35例患者和糖
尿病合并非糖尿病肾病(NDRD)组22例患者进行临床和病理资料分析，并与同期汉族比较。结果 57例2型糖
尿病并肾病患者平均年龄（54±10.64）岁，男女比例为 1.48:1，NDRD占 38.6%，DN组与NDRD组在年龄、糖尿病
病程、高血压方面差异无统计学意义，单纯DN患者镜下血尿较合并NDRD患者发生率低(45.5% vs 77.3%，P<
0.05)，糖尿病视网膜病变发生比例DN组高于NDRD组（48.6% vs 22.7%，P<0.05）。NDRD病理类型最常见的是
IgA肾病 10例(45.5%)、膜性肾病 5例(22.7%)、高血压肾小球硬化 3例(13.6%)。与同期汉族患者比较，维吾尔族
NDRD的糖尿病病程更短[(37.1±16.1) d vs (19.4±22.3) d，P<0.05]，肾功能不全发生比例更高(13.6% vs 14.9%)。
结论 维吾尔族2型糖尿病合并肾病患者可以出现NDRD，血尿、与病程不平行的肾病性蛋白尿、出现蛋白尿却
无糖尿病视网膜病变时，提示可能合并NDRD，在NDRD中 IgA肾病最常见，与同期汉族比较，维吾尔族患者
NDRD的糖尿病病程更短，肾功能不全发生比例更高。

      【关键词】 维吾尔族；糖尿病合并肾病；肾活检

      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2014）01—0114—03


Clinical and pathological analysis of 57 cases of Ughurs with diabetic nephropathy received renal biopsy.
YANG
Shu-fen, ZHANG Ling, HE Wei, YUE Hua. Department of Nephrology, People's Hospital of Xinjiang Uygur Autonomous
Region, Urumqi 830000, Xingjiang, CHINA

【Abstract】 Objective To analyze the clinical and pathological characteristics of diabetic nephropathy in
Uygur patients. Methods According to the renal biopsy results, 57 Uygur patients with type 2 diabetes collected
from January 2003 to December 2012, were divided into diabetic nephropathy (DN) group (n=35) and non-diabetic ne-
phropathy (NDRD) group (n=22), and their clinical and pathological characteristics were analyzed and compared with
the Han nationality's. Results The average age was (54.00±10.64) years, the sex ratio was 1.48:1, and NDRD ac-
counted for 38.6%, There was no differences of age, duration of diabetes, high blood pressure between two groups.
However, simple microscopic haematuria merged NDRD patients was higher (45.5% vs 77.3%, P<0.05), the propor-
tion of diabetic retinopathy in DN group was higher than that in NDRD (48.6% vs 22.7%, P<0.05). NDRD IgA ne-
phropathy was the most common pathological type (45.5%), the secdend was membranous nephropathy (22.7%), and
the third was hypertension, glomerular sclerosis (13.6%). Compared with the Han Chinese, Uygur NDRD in the same
period had shorter duration of diabetes [(37.1+16.1) d vs (19.4+22.3) d, P<0.05), and renal insufficiency were higher
(13.6% vs 14.9%). Conclusion The Uygur patients with type 2 diabete and kidney disease can be easy to appear
NDRD, hematuria, and course of unparallel nephropathy proteinuria, which suggests IgA nephropathy is the most
common in NDRD. Compared with in the same period the Han nationality, Uygur patients with NDRD have shorter
duration of diabete, higher proportion of renal insufficiency.

      【Key words】 Uygur; Diabetic nephropathy; Renal biopsy
·临床病理·