标题:Cys C、NGAL和IL-18对肾病综合征所致急性肾损伤的诊断价值
作者:李冰心,周小兵,杨 林,夏敬彪,张祥文
(宜昌市三峡大学第一临床医学院,湖北 宜昌 443003)
卷次:
2014年25卷1期
【摘要】 目的 探讨血清胱抑素C (Cys C)和尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、白细胞介
素-18 (IL-18)对原发性肾病综合征(PNS)导致的急性肾损伤(AKI)的诊断价值。方法 收集我院PNS患者60例,
其中PNS未并发AKI (非AKI组)患者38例,PNS并发AKI患者(AKI组) 22例。检测血清Cys C、血肌酐、尿素氮、
血脂、白蛋白、24 h尿蛋白定量水平,采用ELISA方法检测尿NGAL和 IL-18水平。结果 AKI组血清Cys C、尿
NGAL和 IL-18显著高于非AKI组,差异有统计学意义。AKI组血Cys C、尿NGAL和 IL-18与肌酐呈正相关,与
eGFR呈负相关。多因素Logistic回归分析结果显示血Cys C、尿NGAL和 IL-18升高是PNS并发AKI的独立危
险因素。结论 血清Cys C、尿NGAL和 IL-18对诊断PNS导致的AKI有较高的准确性。
【关键词】 急性肾损伤;胱抑素C;中性粒细胞明胶酶相关脂质运载蛋白;白细胞介素-18
【中图分类号】 R692 【文献标识码】 A 【文章编号】 1003—6350(2014)01—0053—03
Value of Cys C, NGAL and IL-18 in the diagnosis of acute kidney injury caused by nephrotic syndrome.
LI
Bing-xin, ZHOU Xiao-bing, YANG Lin, XIA Jing-biao, ZHANG Xiang-wen. The First College of Clinical Medical
Science, Three Gorges University, Yichang 443003, Hubei, CHINA
【Abstract】 Objective To assess the values of serum cystatin C (Cys C) and urinary neutrophil gelatinase-as-
sociated lipocalin (NGAL), interleukin-18 (IL-18) in the diagnosis of acute kidney injury (AKI) caused by primary ne-
phrotic syndrome (PNS). Methods Sixty patients with PNS were collected in our hospital, including 38 not compli-
cated with AKI (non-AKI group) and 22 complicated with AKI (AKI group). The levels of serum Cys C, serum creati-
nine, urea nitrogen, serum lipid, albumin and 24 h urinary protein were measured. Urinary NGAL and IL-18 levels
were measured by ELISA. Results The levels of serum Cys C, urinary NGAL and IL-18 in AKI group were signifi-
cantly higher than those in non-AKI group. The levels of serum Cys C, urinary NGAL, IL-18 were positively correlated
with creatinine and negative correlated with eGFR in AKI group. Logistic regression analysis showed that the increase
of serum Cys C, urinary NGAL, IL-18 were independent predictive biomarkers of AKI in PNS. Conclusion Serum
Cys C, urinary NGAL, IL-18 have good performances in the diagnosis of AKI in PNS.
【Key words】 Acute kidney injury; Cystatin C (Cys C); Neutrophil gelatinase-associated lipocalin (NGAL); In-
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