标题：海南地区淋巴组织增生性病变病理分型与EBV感染的相关性分析

      作者：张 弦，罗志飞，蒙秋萍，解 娜，黄幼生，王明华，翁 阳
    (海南医学院病理教研室，海南 海口 571101)

      卷次： 2013年24卷22期

      【摘要】 目的 分析海南地区淋巴组织增生性病变的病理分型及其与EB病毒感染的关系。方法 收集我院
最近5年淋巴组织增生性病变共524例，并对其中有完整资料的214例病例应用EB病毒编码小RNA (EBER)原位杂
交检测淋巴组织中EB病毒(EBV)感染情况，分析EBV与不同类型淋巴瘤和淋巴结反应性增生的关系。结果 157
例淋巴瘤进行了EBER检测，共有40例EB病毒(EBV)阳性，阳性率为25.48%，199例淋巴结反应性增生病变中，
57例进行了EBER原位杂交检测，其中仅3例与EBV感染有关，阳性率为5.26%。结论 EBV与淋巴瘤，特别是
T细胞淋巴瘤的发生有一定关系，以副皮质区增生为主的淋巴结反应性增生可能与EBV感染有关。

      【关键词】 EBV；原位杂交；淋巴瘤；淋巴结反应性增生

      【中图分类号】 R551.2 【文献标识码】 A 【文章编号】 1003—6350（2013）22—3292—04


Exploration on the relationship between EB virus infection and the pathologic classification of
lymphoproliferative disorders in Hainan.
ZHANG Xian, LUO Zhi-fei, MENG Qiu-ping, XIE Na, HUANG You-sheng,
WANG Ming-hua, WENG Yang. Department of Pathology, Hainan Medical University, Haikou 571101, Hainan, CHINA

【Abstract】 Objective To explore the relationship between Epstein-Barr virus (EBV) infection and the patho-
logic classification of lymphoproliferative disorders in Hainan. Methods In situ hybridization (ISH) for EBV-encod-
ed small RNA (EBER) was performed to detect the infection of EBV in 214 patients, selected from 524 patients with
lymphoproliferative disorders in our hospital in the recent 5 years. The relationship between EBV infection and the
pathologic classification of lymphoproliferative disorders was analyzed. Results The positive cases of EBER in lym-
phoma (157 cases) was 40, with the positive rate of 25.48%, including 4 (3.96%) in 101 cases of B-cell non-Hodgkin
lymphoma (B-NHL), 27 (61.36%) in 44 cases of T-cell non-Hodgkin lymphoma (T-NHL), and 9 (75%) in 12 cases of
classical Hodgkin lymphoma mixed cellularity (CHL-MC). The positive cases of EBER in lymph node reactive hyper-
plasia (57 of the 199 cases tested) was 3, with the positive rate of 5.26%. Conclusion There is a correlation between
EBV infection and Lymphoma, especially T-cell lymphoma, and also between EBV infection and lymph node reactive
hyperplasia

      【Key words】 Epstein-Barr virus (EBV); In situ hybridization; Lymphoma; Lymph node reactive hyperplasia
·论 著·