标题：Th17/Treg失衡在类风湿性关节炎发病机制中的研究

      作者：章婷婷，骆春艳 综述，王嘉军 审校
    (三峡大学医学院检验科，湖北 宜昌 443002)

      卷次： 2013年24卷20期

      【摘要】 类风湿性关节炎(Rheumatoid arthritis，RA)是一种临床常见的自身免疫性疾病，严重影响患者的生
活质量。免疫细胞在其发生、发展中发挥重要作用，然而对其具体发病机制目前尚不十分清楚。辅助性T细胞
17(Th17)是一类以分泌 IL-17为主、可介导RA炎症反应过程的细胞；而调节性T细胞(Treg)则具有免疫抑制作
用，Th17/Treg失衡在RA的发病机制中扮演重要角色。本文主要就Th17与Treg的相互作用及Th17/Treg失衡在
RA发病机制中的作用做简要综述。

      【关键词】 类风湿性关节炎、Th17、Treg、发病机制

      【中图分类号】 R593.22 【文献标识码】 A 【文章编号】 1003—6350（2013）20—3035—04


Research of imbalance of Th17/Treg in the pathogenesis of rheumatoid arthritis.
ZHANG Ting-ting, LUO
Chun-yan, WANG Jia-jun. Medical School, China Three Gorges University, Yichang 443002, Hubei, CHINA
【Abstract】 Rheumatoid arthritis is a common clinical autoimmune diseases, which seriously affected the quali-
ty of life of patients. Immune cells play an important role in the occurrence as well as the development of RA, but its
specific pathogenesis is still not clear. T helper 17 cells (Th17) mainly secrete IL-17 and can mediate the inflammato-
ry response of rheumatoid arthritis, while regulatory T cells suppress the immune response. The imbalance of Th17/
Treg is of great significance to the pathogenesis of rheumatoid arthritis. This review mainly focuses on the interaction
between Th17 and Treg and the effect of Th17/Treg imbalances in the pathogenesis of RA.

      【Key words】 Rheumatoid arthritis; Th17; Treg; Pathogenesis
·综 述·doi:10.3969/j.issn.1003-6350.2013.20.1264