标题：不同类型的胃炎和胃癌组织中p21、p16蛋白的表达及临床意义

      作者：李 蓉 1，赵梦云 1，张永红 1，李 荣 2
    (1.西安市第一医院消化科，陕西 西安 710002；
2.西安市第五医院内三科，陕西 西安 710082)

      卷次： 2013年24卷20期

      【摘要】 目的 探讨不同类型胃炎与胃癌的相关性。方法 采用免疫组化法检测p21、p16在疣状胃炎、非
萎缩性胃炎、萎缩性胃炎及胃癌各40例组织中的表达，并对各组值进行比较，得出结论。结果 p21在非萎缩性
胃炎、萎缩性胃炎、疣状胃炎及胃癌组织的表达分别为0、22.5%、35.0%、60.0%，疣状胃炎的p21阳性率显著高于
非萎缩性胃炎，低于胃癌，各组间比较差异有统计学意义（P<0.05），但与萎缩性胃炎比较差异无统计学意义；p16
在非萎缩性胃炎、萎缩性胃炎、疣状胃炎及胃癌组织的表达分别为90.0%、50.0%、45.0%、17.5%，疣状胃炎组p16
阳性率显著低于非萎缩性胃炎，明显高于胃癌组，各组间比较差异有统计学意义(P<0.01)，但与萎缩性胃炎比较
差异无统计学意义。结论 Ras基因激活后形成的p21蛋白及抑癌基因p16失活可能参与疣状胃炎的癌变过程。

      【关键词】 疣状胃炎；胃癌；p21蛋白；p16蛋白

      【中图分类号】 R573.3 【文献标识码】 A 【文章编号】 1003—6350（2013）20—2968—02


Expression of p21 and p16 proteins in different gastritis and gastric cancer tissues and the clinical significance.
LI Rong 1, ZHAO Meng-yun 1, ZHANG Yong-hong 1, LI Rong 2.
1. Department of Gastroenterology, First Hospital of
Xi'an City, Xi'an 710002, Shaanxi, CHINA; 2. The Third Department of Internal Medicine, Xi'an No.5 Hospital, Xi’an
710082, Shaanxi, CHINA

【Abstract】 Objective To explore the relationship between different types of gastritis and gastric cancer.
Methods The expression of p21 and p16 proteins in varioliform gastritis, non-atrophic gastritis, atrophic gastritis,
and gastric cancer was detected by immunohistochemistry. The results were compared. Results The positive rate of
p21 protein expression in non-atrophic gastritis, atrophic gastritis, varioliform gastritis, gastric cancer was 0, 22.5%,
35.0%, 60.0%, respectively, which was significantly higher in varioliform gastritis than non-atrophic gastritis, but sig-
nificantly lower than gastric cancer (P<0.05). The positive rate of p16 protein expression in non-atrophic gastritis, atro-
phic gastritis, varioliform gastritis, gastric cancer was 90.0%, 50.0%, 45.0%, 17.5%, respectively, which was signifi-
cantly lower in varioliform gastritis than non-atrophic gastritis, but significantly higher than gastric cancer (P<0.01).
No significant differences were noted between varioliform gastritis and atrophic gastritis. Conclusion Both p21 and
p16 proteins may be involved in the evolution of varioliform gastritis to gastric cancer.

      【Key words】 Varioliform gastritis; Gastric cancer; p21; p16
基金项目：陕西省卫生厅科学研究基金项目(编号：08H16)