标题：溃疡性结肠炎相关性结直肠癌中AOM/DSS模型应用研究

      作者：吴 琼 1，2，郭 蒙 1, 2，叶 华 2，朱宇珍 2，郑学宝 2
    （1.广东医学院药理教研室，广东 湛江 524023；
2.广东医学院广东天然药物研究与开发重点实验室，广东 湛江 524023)

      卷次： 2013年24卷19期

      【摘要】 在化学诱导结肠炎相关性结肠癌模型中，氧化偶氮甲烷(Azoxymethane，AOM)/葡聚糖硫酸钠
(Dextran sodium sulfate，DSS)可以大大缩短结肠炎诱导癌变的时间，重现人类结直肠癌隐窝病灶-腺瘤-腺癌发
展顺序。由于AOM/DSS模型重现率高，以及简单的造模方法，已成为化学预防研究的典型造模方法。本文从
AOM/DSS动物模型、炎症相关性癌症及结直肠癌中AOM/DSS模型的应用、结直肠癌组织学三个方面对炎症相
关性结直肠癌作一综述。

      【关键词】 溃疡性结肠炎相关性结直肠癌；结直肠癌；动物模型；AOM/DSS

      【中图分类号】 R735.3+7 【文献标识码】 A 【文章编号】 1003—6350（2013）19—2880—04


Advances on the application of AOM/DSS model in ulcerative colitis associated colorectal cancer.
WU Qiong 1,2,
GUO Meng 1,2, YE Hua 2, ZHU Yu-zhen 2, ZHENG Xue-bao 2. 1. Department of Pharmacology, Guangdong Medical
College, Zhanjiang 524023, Guangdong, CHINA; 2. Guangdong Key Laboratory for Research and Development of Natural
Drugs, Zhanjiang 524023, Guangdong, CHINA
【Abstract】 Among the chemically induced CRC models, the combination of a single hit of azoxymethane
(AOM) to the inflammatory agent dextran sodium sulpate (DSS) in rodents has proven to dramatically shorten the la-
tency time for induction of CRC and to rapidly recapitulate the aberrant crypt ofci-adenoma-carcinoma sequence that
occurs in human CRC. Because of its high reproducibility and potency, as well as the simple and affordable mode of
application, the AOM/DSS has become an outstanding model for studying colon carcinogenesis and apowerful plat-
form for chemopeventice intervention studies. This review briefly summarizes the current advances in the AOM/DSS
model, inflammation and tumorigenesis in the AOM/DSS, as well as histogenesis of CRC in the AOM/DSS model.

      【Key words】 Ulcerative colitis associated colorectal cancer; Colorectal cancer; Animal model; AOM/DSS
·综 述·