标题：子痫前期患者血清胱抑素C和尿酸检测的临床意义

      作者：罗燕艳，罗小婉，郑树忠
    （中山市博爱医院妇产科，广东 中山 528403）

      卷次： 2013年24卷19期

      【摘要】 目的 评估血清胱抑素C (CysC)、尿酸(UA)在子痫前期患者早期肾脏功能损害中的价值。方法 对
58例轻度子痫前期患者、68例重度子痫前期患者及62例正常晚期妊娠妇女(对照组)血清中CysC、UA、Scr、Urea
水平进行检测。结果 轻、重度子痫前期组的CysC、UA值与正常妊娠组比较，差异均有统计学意义(P<0.05)，且
轻、重度子痫前期组间的差异亦有统计学意义(P<0.05)。虽然Scr、Urea在重度子痫前期组与正常妊娠组间差异
有统计学意义(P<0.05)，但是各组的值均在正常参考值范围内。结论 CysC、UA可作为评估子痫前期肾功能损
害的敏感指标，对其进行动态监测，有利于肾功能损害的早发现、早治疗，改善孕产妇及围生儿结局。

      【关键词】 胱抑素C；尿酸；子痫前期；肾功能损害

      【中图分类号】 R714.24+5 【文献标识码】 A 【文章编号】 1003—6350（2013）19—2875—03


Clinical significance of serum cystatin C and uric acid in early renal injury induced by preeclampsia.
LUO
Yan-yan, LUO Xiao-wan, ZHENG Shu-zhong. Department of Obstetrics and Gynecology, Boai Hospital of Zhongshan,
Zhongshan 528403, Guangdong, CHINA

【Abstract】 Objective To evaluate the values of serum cystatin C and uric acid in the diagnosis of early renal
injury induced by preeclampsia. Methods The serum levels of cystatin C (Cys C), Uric acid (VA), Serum creatinine
(Scr) and Urea were detected in 58 patients with mild preeclampsia (mild preeclampsia group), 68 patients with severe
preeclampsia (severe preeclampsia group), and 62 normal late pregnant women (the control group). Results The se-
rum levels of CysC and UA in both mild preeclampsia group and severe preeclampsia group were significantly higher
than those in the control group (P<0.05). Although there were significant differences in Scr, Urea between the severe
preeclampsia group and the control group, the values were within the normal range. Conclusion Both Cys C and UA
are sensitive indexes for early renal injury induced by preeclampsia. Dynamic monitoring of the two indexes plays an
important role in detecting the change of renal function and in the early treatment.

      【Key words】 Cystatin C; Uric acid; Preeclampsia; Renal injury