标题：诺和锐30治疗老年初发2型糖尿病的疗效观察

      作者：林李壮，陈 鼎
    （海口市人民医院海港分院内科，海南 海口 570311）

      卷次： 2013年24卷18期

      【摘要】 目的 观察双时相门冬胰岛素30(诺和锐30)治疗老年初发2型糖尿病的疗效，为提高患者生存质
量，降低并发症提供依据。方法 以我院2010年3月至2012年6月收治的132例初发老年2型糖尿病患者为研
究对象，比较使用诺和锐30治疗前后空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇、甘油三脂和体重指数，同
时计算治疗前后HOMA-IR和HOMA-β。结果 治疗 12周后空腹血糖为(5.91±0.96) mmol/L、餐后 2 h血糖为
(7.81±1.83) mmol/L、糖化血红蛋白为(5.80±0.63)%，与治疗前比较明显下降，差异有统计学意义(P<0.05)；治疗前
后总胆固醇和甘油三脂均有改善，差异有统计学意义(P<0.05)，但治疗前后体重指数差异无统计学意义(P>0.05)；
治疗后HOMA-IR与治疗前比较胰岛素抵抗有改善(P<0.05)，HOMA-β与治疗前比较胰岛敏感性增加(P<0.05)；
出现两例低血糖，均予高糖饮食后改善，无夜间低血糖发作。结论 双时相门冬胰岛素30(诺和锐30)治疗老年
初发2型糖尿病安全有效，有利于血糖长期良好控制，值得临床推广。

      【关键词】 诺和锐30；老年；2型糖尿病；疗效

      【中图分类号】 R587.1 【文献标识码】 A 【文章编号】 1003—6350（2013）18—2669—02


Efficacy of novomix 30 in the treatment of the old patients with type 2 diabetes.
LIN Li-zhuang, CHEN Ding.
Department of Internal Medicine Haibour Branch, People's Hospital of Haikou, Haikou 570311, Hainan, CHINA

【Abstract】 Objective To observe the efficacy of novomix 30 in the treatment of the old patients with type 2
diabetes, and to improve the survival quality and reduce mortality. Methods A total of 132 old patients with type 2
diabetes from March 2010 to June 2012 were enrolled into this study. Before and after treatment, the fasting blood glu-
cose, post-prandial glycemia after 2 hours, glycosylated hemoglobin, total cholesterol, triglyceride and body mass in-
dex were compared. HOMA-IR and HOMA-β were calculated. Results After the 12 weeks of treatment, the fasting
blood glucose was（5.91±0.96）mmol/L, post-prandial glycemia after 2 hours was（7.81±1.83）mmol/L and glycosylat-
ed hemoglobin was（5.80±0.63）%, with significant difference compared with those before treatment (P<0.05). The to-
tal cholesterol and triglyceride had significant difference (P<0.05), but body mass index had no significant difference.
Compared with that before treatment, the resistance improved by HOMA-IR (P<0.05) , the sensitivity of insulin in-
creased by HOMA-β after treatment (P<0.05). There were two cases with low blood sugar, and improved after
high-sugar diet, with no nocturnal hypoglycemia. Conclusion Novomix 30 is effective and safe in the treatment for
the old patients with type 2 diabetes.

      【Key words】 Novomix 30; Old; Type 2 diabetes; Efficacy