标题：卵巢上皮性肿瘤中Ezrin、E-cadherin及EGFR的表达及临床意义

      作者：冼丽英，尹有群，赵东晖，赵继红，叶伟标
    (东莞市人民医院病理科，广东 东莞 523000)

      卷次： 2013年24卷18期

      【摘要】 目的 探讨卵巢上皮性肿瘤中Ezrin、E-cadherin和EGFR的表达意义及其与预后的关系。方法 选取
有随访资料的卵巢上皮性肿瘤(包括卵巢癌77例和11例良性、9例交界性卵巢上皮性肿瘤)，并随机选取正常卵巢
组织 7例，应用用免疫组化SP法检测Ezrin、E-cadherin和EGFR的表达。结果 Ezrin和E-cadherin在正常卵巢
组织、良性、交界卵巢上皮肿瘤组织及卵巢癌组织中的表达阳性率呈递减趋势，并与卵巢癌FIGO分期、组织学分
级呈负相关。而EGFR表达的呈上升趋势，其表达与卵巢癌FIGO分期及腹腔种植呈正相关。单因素分析显示
Ezrin和E-cadherin阴性表达患者的累积生存率明显缩短，而EGFR阴性表达患者累积生存率高。多因素COX回
归模型显示：Ezrin、E-cadherin的阴性及EGFR的阳性表达是卵巢癌患者生存独立危险因素。相关分析显示，
Ezrin与E-cadherin的表达呈正相关，与EGFR呈负相关。结论 Ezrin与卵巢癌的浸润及转移密切相关，是卵巢
癌不良预后因素，并协同调节E-cadherin和EGFR而影响卵巢癌细胞的粘附和转移性。

      【关键词】 Ezrin；E-cadherin；EGFR；卵巢癌

      【中图分类号】 R737.31 【文献标识码】 A 【文章编号】 1003—6350（2013）18—2653—05


Expression of Ezrin, E-cadherin and EGFR protein in epithelial ovarian neoplasms and its clinical significance.
XIAN Li-ying, YIN You-qun, ZHAO Dong-hui, ZHAO Ji-hong, YE Wei-biao.
Department of Pathology, Dongguan
People's Hospital, Dongguan 523000, Guangdong, CHINA

【Abstract】 Objective To study the expression and clinical significance of Ezrin, E-cadherin and EGFR in
epithelial ovarian neoplasms. Methods We examined expressions of Ezrin, E-cadherin and EGFR in 77 ovarian car-
cinomas, 11 benign tumors and 9 borderline epithelial ovarian tumors and 7 normal ovarian tissue samples by S-P im-
munohistochemistry, respectively. Results Ezrin and E-cadherin had a declining expression in normal ovarian tissue,
benign tumor, borderline epithelial ovarian tumors and ovarian carcinomas, but EGFR had a rising expression. The ex-
pression of Ezrin and E-cadherin revealed a negative correlation with clinical stages but a positive correlation with the
EGFR in ovarian carcinomas. In univariate analysis, negative expression of Ezrin and E-cadherin was associated with
shorter survival, but negative expression of EGFR was correlated with longer survival. Cox multivariate survival anal-
ysis showed that negative expression of Ezrin and E-cadherin and positive expression of EGFR had independent effect
on survival. Conclusion Ezrin may be an independent adverse prognostic factor of ovarian cancer. Ezrin, E-cadherin
and EGFR together influence epithelial ovarian neoplasm to invasion and metastasis.

      【Key words】 Ezrin; E-cadherin; EGFR; Ovarian carcinoma; Prognosis