标题：多西他赛联合顺铂与培美曲塞联合顺铂治疗晚期肺腺癌的随机对照研究

      作者：邹三鹏 1，薛静 2
    (1.广东医学院附属惠东医院肿瘤内科，广东 惠东 516300；
2.西安交通大学第一附属医院呼吸内科，陕西 西安 710061)

      卷次： 2016年27卷8期

      【摘要】 目的 观察多西他赛联合顺铂方案(DP方案)与培美曲塞联合顺铂方案(PP方案)一线治疗晚期肺腺
癌的近期疗效和不良反应。方法 收集2012年8月至2014年8月在西安交通大学第一附属医院(46例)和广东医学
院附属惠东医院(20例)收治的66例初治晚期肺腺癌患者，采用随机对照的临床研究设计，将66例经组织学或细胞
学确诊的初治晚期肺腺癌患者分为DP方案组和PP方案组各33例。观察两组患者的近期有效率(RR)、疾病控制率
(DCR)、疾病进展时间(TTP)、中位生存时间(MST)、1年生存率和不良反应。结果 DP方案组中，部分缓解(PR) 10
例，疾病稳定(SD)15例，疾病进展(PD) 8例，RR为 30.30% (10/33)，DCR为 75.76% (25/33)；TTP为 7.8个月，MST为
13.5个月，1年生存率为 54.55% (18/33)。PP方案组中，PR 11例，SD 16例，PD 6例，RR为 33.33% (11/33)，DCR为
81.82% (27/33)，TTP为8.1个月，MST为14.8个月，1年生存率为57.58% (19/33)。两组患者的近期疗效和生存率比
较差异均无统计学意义(P≥0.05)。两组患者的主要不良反应为血液学毒性、消化道反应和脱发。PP组的不良反应
中中性粒细胞减少、血小板减少及脱发的发生率明显低于DP组，差异具有统计学意义(P<0.05)。结论 DP方案和
PP方案治疗晚期肺腺癌疗效确切，不良反应均可耐受。

      【关键词】 晚期肺腺癌；多西他赛；培美曲塞；顺铂；疗效

      【中图分类号】 R734.2 【文献标识码】 A 【文章编号】 1003—6350（2016）08—1242—04


Prospective randomized controlled clinical trial of docetaxel plus cisplatin versus pemetrexed plus cisplatin as
treatment for advanced lung adenocarcinoma.
ZOU San-peng 1，XUE Jing 2. 1. Department of Oncology, the Affiliated
Huidong Hospital of Guangdong Medical College, Huidong 516300, Guangdong, CHINA; 2. Department of Respiratory
Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi’an 710061, Shaanxi, CHINA

【Abstract】 Objective To prospectively evaluate the efficacy and toxicity of docetaxel plus cisplatin (DP regi-
men) compared with pemetrexed plus cisplatin (PP regimen) as a first-line treatment for advanced lung adenocarcinoma.
Methods Sixty-six patients with advanced lung adenocarcinoma at the beginning of treatment were collected from Au-
gust 2012 and August 2014 in the First Affiliated Hospital of Xi'an Jiaotong University (46 cases) and the Affiliated Hui-
dong Hospital of Guangdong Medical College (20 cases). The patients were randomly assigned to two regimens: DP regimen
(DP group, n=33) and PP regimen (PP group, n=33). The response rate (RR), disease control rate (DCR), time to disease pro-
gression (TTP), median survival time (MST), 1-year survival rate, and side effects were observed. Results Among the 33
cases of DP group, there were 10 cases of partial response (PR), 15 cases of stable disease (SD) and 8 cases of progres-
sive disease (PD), with the RR and DCR of 30.30% (10/33) and 75.76% (25/33), respectively. The TTP, MST, the 1-year
survival rate were 7.8 months, 13.5 months, 54.5% (18/33), respectively. Among the 33 cases in the PP group, there were
11 cases of PR, 16 cases of SD and 6 cases of PD, with the RR and DCR of 33.33% (11/33) and 81.82% (27/33), respec-
tively. The TTP, MST, and the 1-year survival rate were 8.1 months. 14.8 months, 57.58% (19/33), respectively. Recent
efficacy and survival rates showed no statistically significant difference between the two groups. The main side effects of
the two groups included hematologic toxicities, digestive tract reaction and hair loss. The incidence of neutropenia, throm-
·论 著·
6350.2016.08.012