标题：补锌疗法佐治婴幼儿轮状病毒肠炎的临床效果观察

      作者：杨 敏
    （重庆市长寿区人民医院儿科，重庆 401220）

      卷次： 2013年24卷15期

      【摘要】 目的 观察补锌疗法对轮状病毒肠炎治疗的效果。方法 将2010年8月至2012年10月间收治的
140例轮状病毒肠炎患儿随机分为观察组(n=76)与对照组(n=64)，对照组患儿给予病毒唑、蒙脱石散、西咪替丁及
补液纠酸等综合疗法，观察组在此基础上加服葡萄糖酸锌片或甘草锌颗粒，治疗72 h后观察两组临床疗效，治疗
14 d后对比两组血锌含量与免疫球蛋白水平。结果 ①治疗后2周，患儿血锌与 IgG、IgA、IgM含量均有所上升，
观察组血锌、IgG、IgA水平明显高于对照组 (P<0.05)。②治疗后观察组腹泻持续天数为(6.21±1.52) d，明显少于
对照组的(7.14±1.82) d (P<0.05)。③治疗72 h后，两组患儿临床疗效构成不同，观察组总体有效率与显效率均高
于对照组(P<0.05)。结论 婴幼儿轮状病毒肠炎在常规基础上佐以补锌疗法能提高患儿免疫功能，缩短病程，提
高治疗有效率。

      【关键词】 轮状病毒肠炎；葡萄糖酸锌；甘草锌；免疫球蛋白；疗效

      【中图分类号】 R725.1 【文献标识码】 A 【文章编号】 1003—6350（2013）15—2233—03


Clinical efficacy of zinc in the adjunctive treatment of infantile rotavirus enteritis.
YANG Min. Department of
Pediatrics, People's Hospital of Changshou District of Chongqing, Chongqing 401220, CHINA

【Abstract】 Objective To observe the clinical efficacy of zinc in the treatment of infantile rotavirus enteritis.
Methods One hundred and forty patients admitted from Aug. 2010 to Oct. 2012 were randomly divided into the
treatment group (n=76) and the control group (n=64). The control group was given ribavirin+cimetidine+smectite ther-
apeutic regimen and symptomatic treatment, based on which the treatment group was added with zinc gluconate or
zinc glycyrrhetate granules orally. After treatment for 72 h, the clinical efficacy of the two groups was compared, and se-
rum zinc level, immunoglobulin level were checked and compared after treatment for 14 d. Results ①After treatment
for 14 d, serum zinc and IgG, IgA, IgM all increased, and zinc, IgG, IgA levels of the treatment group were significant-
ly higher than those of the control group (P<0.05).②After treatment, diarrhea duration of the treatment group [(6.21±
1.5) d] was significantly lower than that of the control group [(7.14±1.8) d], P<0.05. ③ After treatment for 72 h, the
overall effective rare and markedly effective rate of the treatment group were both significantly higher than those of
the control group (P<0.05). Conclusion For infantile rotavirus enteritis, zinc supplementation based on regular therapy
can improve children’s immune function, shorten diarrhea course, and improve the treatment efficiency.

      【Key words】 Rotavirus enteritis; Zinc gluconate; Licorzinc; Immunoglobulin; Clinical efficacy