标题：不同剂量阿托伐他汀治疗急性冠脉综合征80例临床分析

      作者：陈 卓，吕美平
    （深圳市龙华人民医院心血管内科，广东 深圳 518109）

      卷次： 2013年24卷15期

      【摘要】 目的 观察不同剂量阿托伐他汀治疗急性冠脉综合征的临床疗效和安全性。方法 将我院收治
的急性冠脉综合征患者 80例随机分为两组，各 40例。低剂量组患者口服阿托伐他汀 10 mg/d，高剂量组患者
口服阿托伐他汀 40 mg/d，随访 12个月。观察两组患者血脂变化情况、心血管事件发生情况及药物不良反应。
结果 治疗前两组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇
(HDL-C)水平比较差异无统计学意义(P>0.05)。低剂量阿托伐他汀和高剂量阿托伐他汀均能有效的降低血浆
TC、TG、LDL-C水平，HDL-C明显升高，与治疗前比较差异有统计学意义(P<0.05)，但治疗3个月后高剂量组各项
指标明显优于低剂量组(P<0.05)。高剂量组达标速度更快，治疗1个月、3个月、6个月时达标率明显优于低剂量
组(P<0.05)。随访 1年，高剂量组心血管事件发生率明显低于低剂量组(P<0.01)。两组无明显不良反应发生。
结论 较大剂量阿托伐他汀治疗急性冠脉综合征能够使患者血脂水平迅速达标，降低心血管事件发生率，40 mg/d
的剂量是安全有效的，可在临床推广应用。

      【关键词】 急性冠脉综合征；阿托伐他汀；预后；心血管事件

      【中图分类号】 R541.4 【文献标识码】 A 【文章编号】 1003—6350(2013)15—2202—03


Efficacy and safety of different doses of atorvastatin in the treatment of 80 cases of acute coronary syndrome.
CHEN Zhuo, LV Mei-ping.
Department of Cardiovascular Internal Medicine, Shenzhen Longhua People's Hospital,
Shenzhen 518109, Guangdong, CHINA

【Abstract】 Objective To observe the efficacy and safety of different doses of atorvastatin in the treatment of
acute coronary syndrome. Methods Eighty patients of acute coronary syndrome in our hospital were randomly divid-
ed into two groups, with 40 patients in each group. Low dose group were treated with atorvastatin 10 mg/d, high dose
group were given atorvastatin 40 mg/d. The patients were followed up for 12 months. The change of cholesterol, car-
diovascular events and adverse drug reactions were observed. Results Before treatment, the total cholesterol (TC),
triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) of
two groups showed no statistically significant difference (P>0.05). Low dose atorvastatin and high dose atorvastatin
can effectively reduce the plasma TC, TG, LDL-C. The levels of HDL-C increased significantly after treatment, com-
pared with before treatment (P<0.05). Three months after treatment, the indexes of high dose group was better than
those of low dose group (P<0.05). High dose group reached the target faster, and the compliance rate was higher than
that of low dose group after 1 months, 3 months, 6 months of treatment (P<0.05). During the follow-up, the incidence
of cardiovascular events in high dose group was significantly lower than that in low dose group (P<0.01). The two
groups had no obvious adverse reactions. Conclusion High dose of atorvastatin in the treatment of acute coronary
syndrome can make the blood lipid levels of patients reach the target quickly and reduce the incidence of cardiovascu-
lar events, which is safe and effective at the dose of 40 mg/d.

      【Key words】 Acute coronary syndrome; Atorvastatin; Prognosis; Cardiovascular events