标题：纳洛酮联合神经节苷脂治疗急性大面积脑梗死40例疗效观察

      作者：谭向红
    (中山市小榄人民医院神经内科，广东 中山 528415)

      卷次： 2013年24卷15期

      【摘要】 目的 探讨早期联合应用纳洛酮和神经节苷脂治疗急性大面积脑梗死的临床疗效。方法 将
2010年2月至2013年2月期间我院诊治的80例急性大面积脑梗死患者随机分为对照组（常规治疗）和观察组（对
照组基础上，加用纳洛酮和神经节苷脂），治疗14 d，根据格拉斯哥（GCS）预后评分标准，观察和比较两组患者的
临床疗效、清醒时间以及日常生活能力（ADL）评分。结果 观察组治疗的总有效率为 80.0%，相较于对照组
（57.5%）明显提高；清醒时间为（12.0±4.5）d，相较于对照组(18.0±5.0) d明显缩短；ADL评分为（68.0±18.0）分，相
较于对照组(52.0±16.0)分明显升高；差异均具有统计学意义（P＜0.05）。结论 早期联合应用纳洛酮和神经节苷
脂治疗急性大面积脑梗死患者疗效显著，值得临床推广。

      【关键词】 纳洛酮；神经节苷脂；脑梗死；疗效

      【中图分类号】 R743.33 【文献标识码】 A 【文章编号】 1003—6350（2013）15—2200—02


Clinical efficacy of naloxone combined with ganglioside in the treatment of patients with acute large area
cerebral infarction.
TAN Xiang-hong. Department of Neurology, Xiaolan People's Hospital in Zhongshan City,
Zhongshan 528415, Guangdong, CHINA

【Abstract】 Objective To study the clinical efficacy of early application of naloxone combined with ganglioside
in the treatment of patients with large area cerebral infarction. Methods Eighty patients with acute large area cerebral in-
farction in our hospital during the period from Feb. 2010 to Feb. 2013 were randomized into the control group (routine
treatment) and the observation group (applied naloxone and ganglioside based on routine treatment,). According to GCS
sores, the clinical efficacy, awake time and ADL scores in the two groups after 14 days of treatment were observed and
compared. Results The total effective rate of the observation group was 80.0%, significantly higher than that of the con-
trol group (57.5%); the awake time of the observation group was (12.0±4.5) days, significantly shorter than that of the
control group [(18.0±5.0) days]; the ADL scores of the observation group was (68.0±18.0), significantly higher than that
of the control group [(52.0±16.0)]. The differences between the two groups were all statistically significant (P<0.05).
Conclusion For treating patients with acute large area cerebral infarction, naloxone combined with ganglioside has signif-
icant clinical efficacy and improves the patients' prognosis, which is worthy of clinical promotion.

      【Key words】 Naloxone; Ganglioside; Cerebral infarction; Efficacy