标题：不同剂量阿托伐他汀治疗老年血脂正常冠心病患者的临床疗效分析

      作者：杨章丽，陈良剑
    （南宁市第三人民医院心血管内科，广西 南宁 530003）

      卷次： 2013年24卷14期

      【摘要】 目的 探讨不同剂量阿托伐他汀治疗老年血脂正常冠心病患者的临床疗效。方法 将150例老年
血脂正常的冠心病患者随机分为治疗组(75例)和对照组(75例)，在常规治疗基础上，对照组给予阿托伐他汀 10
mg/次，1次/d，口服，疗程6个月，治疗组给予阿托伐他汀40 mg/次，1次/d，口服，疗程6个月。比较两组治疗前后
炎症因子、颈动脉粥样硬化超声特征及6个月内不良心脑血管事件(MACCE)的差别。结果 治疗后治疗组血清
hsCRP、IL-6、TNF-α均显著低于对照组(P<0.05)；随访 6个月内，治疗组MACCE发生率均显著低于对照组(P<
0.05)；两组患者治疗后斑块积分、斑块偏心指数、管腔最大狭窄率明显降低，其中治疗组患者斑块积分降低程度
显著低于对照组，差异具有统计学意义(P<0.05)。结论 大剂量的阿托伐他汀治疗老年血脂正常冠心病患者，控
制炎症效果更为理想，可延缓动脉粥样硬化的进展，显著降低心血管事件发生率，改善预后。

      【关键词】 冠心病；阿托伐他汀；血脂；心血管事件；老年

      【中图分类号】 R541.4 【文献标识码】 A 【文章编号】 1003—6350（2013）14—2044—03


Effect of different doses of atorvastatin in the treatment of elderly coronary artery disease patients with normal
lipid.
YANG Zhang-li, CHEN Liang-jian, CHEN Liang-jian. Department of Cardiology, The Third People's Hospital of
Nanning, Nanning 530003, Guangxi, CHINA

【Abstract】 Objective To explore the effect of atorvastatin in the treatment of elderly coronary artery disease
patients with normal lipid, and to investigate its influence on prognosis. Methods One hundred and fifity elderly cor-
onary artery disease patients with normal lipid were randomly divided into the control group (n=75) and the study
group (n=75). The control group received routine treatment with 10 mg atorvastatin orally, once a day for 6 months.
The study group was added 40 mg atorvastatin orally, once a day for 6 months, based on routine treatment. The expres-
sion of inflammatory factors level, ultrasound characteristics of carotid atherosclerosis, and the occurrence rate of
MACCE before and after treatment were compared between the two groups. Results The levels of hsCRP, IL-6 and
TNF-α after treatment in the study group were significantly lower than those in the control group (P<0.05). The occur-
rence rate of MACCE during the follow-up in the study group were significantly lower that those in the control group
(P<0.05). Compared with the control group, the ultrasound characteristics such as plaque score increased after treat-
ment in the study group (P<0.05). Conclusion For elderly coronary artery disease patients with normal lipid, atorvas-
tatin has ideal effect in controlling inflammation, which can delay the progress of atherosclerosis, decrease the major
cardiovascular events, and improve the heart function and prognosis.

      【Key words】 Coronary artery disease; Atorvastatin; Lipid; Cardiovascular Event; Elderly