标题：血管紧张素Ⅱ１型受体基因多态性与冠心病的相关性研究

      作者：王选琦，燕醒狮，吴晓明，陈中升，吴晓鹏
    （陕西省第四人民医院心血管内科，陕西 西安 710043）

      卷次： 2013年24卷14期

      【摘要】 目的 探讨血管紧张素Ⅱ１型受体多态性与冠心病的相关性，提高临床用药效果。方法 选择我
院于2011年1月至2012年3月心内科住院的患者90例分入冠心病组；选择同期健康体检者(冠心病相关指标检
查后均属正常，且无相关病史及家族史) 60例分入健康组，采用分组对照的方法比较分析。两组均采用
PCR-RFLP技术检测 AT1 R多态性；通过造影技术检测冠心病组患者的病情严重程度。结果 通过
AT1R-A1166/C基因观测检测出两种基因：AA型、AC型；AA、AC基因型及等位基因频率（健康组及冠心病组中
检测结果没有发现CC型）的检测结果两组比较差异无统计学意义(P>0.05)；病变指数及危险统计AC型高于AA
型，差异具有统计学意义(P<0.05)。结论 血管紧张素Ⅱ１型受体多态性不是冠心病发生的主要原因，但与冠脉
病变严重程度有关，该研究结果在临床用药指导中具有重要意义。

      【关键词】 相关性；多态性；冠心病

      【中图分类号】 R541.4 【文献标识码】 A 【文章编号】 1003—6350（2013）14—2040—03


Correlation of angiotensinⅡ receptor gene polymorphism with coronary heart disease.
WANG Xuan-qi, YAN
Xing-shi, WU Xiao-ming, CHEN Zhong-sheng, WU Xiao-peng. Department of Cardiology, the Fourth People's Hospital
of Shanxi Province, Xi’an 710043, Shaanxi, CHINA

【Abstract】 Objective To explore the correlation between angiotensinⅡ type 1 receptor gene polymorphism
and coronary heart disease, and to improve the effect of clinical medicine. Methods Ninety hospitalized patients in
the Department of Cardiology in our hospital from January 2011 to March 2012 were selected as the CHD group,
while 60 healthy subjects were enrolled as the control group (coronary heart disease-related indicators are normal, no
relevant medical history and family history). AT1 R polymorphism were detected by PCR-RFLP, the severity of the pa-
tient's condition was detected by angiography. Results By observing the AT1R-A1166/C, two genes were detected:
AA genotype, AC genotype. The AA, AC genotype and allele frequencies showed no statistically significant difference
between the two groups (P>0.05). The lesion score and risk statistics for AC genotype were higher than thsoe of AA
genotype, and the difference was statistically significnat (P<0.05). Conclusion Angiotensin Ⅱ type 1 receptor gene
polymorphism is not the main reason for coronary heart disease, but it is correlated with the severity of coronary artery
disease. The results provide great significance in the clinical medication.

      【Key words】 Correlation; Polymorphism; Coronary heart disease
·论 著·