标题：儿童过敏性紫癜肾脏损害相关危险因素分析

      作者：唐 芳
    （深圳市坪山新区人民医院儿科，广东 深圳 518118）

      卷次： 2013年24卷13期

      【摘要】 目的 探讨过敏性紫癜（Henoch-Schonlein prupura，HSP）患儿肾脏损害的危险因素。方法 选取
80例过敏性紫癜患儿，其中非HSP肾脏损害患儿60例为对照组，HSP肾脏损害患儿20例为观察组。分析两组患
者一般临床资料，研究因素包括男/女比例、年龄≥8岁、皮疹反复≥4周、消化道出血、腹痛、关节痛、血WBC、
PLT、IgG、FIB、ASO及C3。首先进行单因素分析，而后对具有显著差异者行多因素分析。结果 通过单因素分
析，显示两组患者年龄、皮疹反复≥4周、腹型、IgG、血FIB升高差异具有统计学意义；经Logistic回归分析显示皮
疹反复≥4周、腹型、IgG是HSP患儿肾脏损害的危险因素。结论 针对HSP肾脏损害危险因素，做好相应预防
和随访措施。

      【关键词】 过敏性紫癜；肾脏损害；危险因素；临床分析

      【中图分类号】 R725.5 【文献标识码】 A 【文章编号】 1003—6350（2013）13—1928—03


Risk factors of kidney damage in children of allergic purpura.
TANG Fang. Department of Pediatrics, People's
Hospital of Pingshan New District of Shenzhen City, Shenzhen 518118, Guangdong, CHINA

【Abstract】 Objective To explore the risk factors of kidney damage in children with allergic purpura (He-
noch-Schonlein prupura, HSP). Methods Eighty children with allergic purpura were enrolled in this study, including
60 cases without kidney damage (the control group) and 20 cases with kidney damage (the observation group). The
clinical data of the two groups were analyzed, including male-female ratio, age≥8 years old, rash repeatedly ≥4
weeks, gastrointestinal bleeding, abdominal pain, joint pain, blood WBC, PLT, IgG, FIB, ASO and C3. Univariate anal-
ysis and multivariate analysis were applied. Results Univariate analysis showed that age, rash repeatedly ≥4
weeks, abdominal, IgG, elevated blood FIB were significantly different between the two groups. Logistic regression
analysis showed that rash repeatedly ≥4 weeks, abdominal, IgG were the risk factors for kidney damage in HSP
children. Conclusion Corresponding prevention and measures should be taken against the risk factors for kidney
damage in HSP children.

      【Key words】 Allergic purpura; Kidney damage; Risk factors; Clinical analysis