标题：天津地区女性人乳头瘤病毒感染情况及亚型分布特征分析

      作者：吴林玲，闫 颖，韩志平
    (天津中医药大学第一附属医院妇科，天津 300193)

      卷次： 2013年24卷13期

      【摘要】 目的 研究 23种 HPV基因亚型在天津地区女性中的感染状况以及亚型分布特征，为预防 HPV
感染和宫颈癌防治提供依据。方法 利用 DNA杂交技术检测妇科门诊样本，并进行基因分型，比较不同亚型流
行病学的特点。结果 3 350例样本中HPV感染者1 048例，感染率为31.28%，其中高危亚型检出652例，占感染
者的62.21%，低危亚型 229例，占21.85%，同时感染高危亚型和低危亚型的 167例，占15.93%。各年龄组均以单
重感染为主，其次为二重感染。在5个年龄组中，≤25岁年龄段感染比例最高。23个亚型中以16型最多，其次
为58型和56型。结论 天津地区女性HPV感染以单重感染为主，高危亚型的感染具有一定优势；高危亚型中，
HPV16、58和 56为主要感染亚型。

      【关键词】 人乳头瘤病毒；基因分型；DNA 杂交

      【中图分类号】 R730.261 【文献标识码】 A 【文章编号】 1003—6350（2013）13—1922—04


Infection and genotype distribution of human papilloma virus in females in Tianjin.
WU Lin-ling, YAN Ying,
HAN Zhi-ping. Department of Gynecology, the First Affiliated Hospital of Tianjin University of Traditional Chinese
Medicine, Tianjin 300193, CHINA

【Abstract】 Objective To study the prevalence and molecular epidemiological characteristics of 23 geno-
types of human apillomavirus (HPV) inTianjin, and to provide theoretical basis for preventing and treating uterine cer-
vical cancer. Methods All samples were detected for HPV genotypes by using DNA hybridization technique, and the
molecular epidemiological characteristics of 23 HPV types were compared. Results Among the 3 350 samples, 1
048 cases were HPV, with the positive rate of 31.28% ; 652 cases belonged to high-risk type only, accounting for
62.21% of HPV positive cases; 229 (21.85%) cases belonged to low-risk type, while 167 (15.93%) cases were mixed
with high-risk type and low-risk type. Subtype HPV16 occupied the first of all high-risk types, followed by subtype
HPV58 and HPV56. The most common HPV infection in 5 age groups was single genotype, followed by double
HPV genotypes. Compared with other age groups, the infection rate of the group with age≤25 years old was the high-
est. HPV16 genotype was the most common HPV infection type, and HPV58 and HPV56 are the major subtypes.
Conclusion The most common HPV infection is single genotype in Tianjin. The predominate high risk subtype are
HPV16, HPV58 and HPV56.

      【Key words】 Human papillomavirus; Genotype; DNA hybridization