标题：传统与新型抗癫痫药物治疗新诊断癫痫患者的一年保留率比较

      作者：郭丽冰，吴志刚，李济田，卢惠娴，杜韵华，吴伟博
    (佛山市第三人民医院神经内科，广东 佛山 528000)

      卷次： 2013年24卷13期

      【摘要】 目的 比较一线的传统与新型的抗癫痫药物治疗新诊断癫痫患者的保留率，为癫痫患者维持治疗
的药物选择提供依据。方法 通过门诊随诊对269例新诊断的癫痫患者按发作类型随机给予苯妥英钠、丙戊酸
钠、卡马西平、拉莫三嗪、托吡酯、奥卡西平单药治疗，比较它们的一年保留率，并详细记录停药原因。结果 一
年保留率统计，传统的抗癫痫药物分别为苯妥英钠63.5%、丙戊酸钠67.3%、卡马西平68.6%，新型的抗癫痫药物
分别为拉莫三嗪88.5%、托吡酯74.5%、奥卡西平75%，传统与新型抗癫痫药物的一年保留率比较差异均有统计学
意义(P＜0.05)。在停药的原因方面，传统抗癫痫药物(52.5%)比新型抗癫痫药物(26.7%)更容易因为药物副作用
而停药，两者比较差异也有统计学意义(P＜0.05)。结论 新型抗癫痫药物治疗新诊断癫痫患者的一年保留率较
传统的抗癫痫药物高，提示对于新诊断癫痫患者应优先选择新型的抗癫痫药物作为单药治疗。

      【关键词】 保留率；癫痫；传统抗癫痫药物；新型抗癫痫药物

      【中图分类号】 R742.1 【文献标识码】 A 【文章编号】 1003—6350(2013)13—1895—03


Comparison of one year retention rate between traditional and new antiepileptic drugs in patients with newly
diagnosed epilepsy.
GUO Li-bing, WU Zhi-gang, LI Ji-tian, LU Hui-xian, DU Yun-hua, WU Wei-bo. Department of
Neurology, the Third People's Hospital of Foshan City, Foshan 528000, Guangdong, CHINA

【Abstract】 Objective To compare the retention rate of traditional antiepileptic drugs and new antiepileptic
drugs in the treatment of newly diagnosed epileptic patients, and to provide basis for drug selection of maintenance
treatment. Methods A total of 269 epileptic patients newly diagnosed in the Outpatient Department were randomly
given single drug therapy according to seizure types, including traditional antiepileptic drugs (Phenytoin, Sodium Val-
proate, Carbamazepine) and new antiepileptic drugs (Lamotrigine, Oxcarbazepine and Topiramate). The retention
rates were compared after one year, and the reasons for withdrawal in detail were recorded. Results The one year re-
tention rates of new antiepileptic drugs [Lamotrigine (88.5%), Oxcarbazepine (75%), Topiramate (74.5%)] were signif-
icantly different from those of traditional antiepileptic drugs [Phenytoin (63.5%), Sodium Valproate (67.3%), Carbam-
azepine (68.6%)]. Patients treated with traditional antiepileptic drugs (52.5%) were much more likely to withdraw than
those treated with new antiepileptic drugs (26.7%) because of side effects. Conclusion The retention rate of new an-
tiepileptic drugs is significantly higher than the traditional antiepileptic drugs in newly diagnosed epileptic patients. To
select new antiepileptic drugs as first monotherapy for patients with newly diagnosed epilepsy is rational.

      【Key words】 Retention rate; Epilepsy; Traditional antiepileptic drugs; New antiepileptic drugs
3 讨 论