标题：131碘治疗Graves病的临床价值

      作者：蒋炳辰 1，高永旺 1，张雪辉 1，肖国有 2，姚少红 1
    (1.北海市人民医院核医学科，广西 北海 536000；
2.广西医科大学附属肿瘤医院核医学科，广西 南宁 530021）

      卷次： 2013年24卷12期

      【摘要】 目的 探讨放射性 131碘（131I）治疗弥漫性毒性甲肿(Graves 病)的临床应用价值。 方法 对 93例
Graves病进行首次 131I治疗后观察其效果，并与抗甲亢药物（85例）和手术治疗（82例）的效益比对，进行相关分
析。 结果 首次 131I治疗Graves病总治愈率为68.8%。总好转率为11.8%，总有效率为80.6%；Graves病 131I治疗
与抗甲亢药物治疗治愈率差异有统计学意义(P<0.05)，治疗周期明显缩短；与手术治疗治愈率比较差异无统计学
意义(P>0.05)，但治疗费用大幅下降。结论 放射性 131碘治疗毒性弥漫性甲肿具有稳定有效、周期短、价格低、安
全性高等特点，在治疗甲亢的领域值得推广。

      【关键词】 放射性 131I治疗；Graves 病；免疫球蛋白

      【中图分类号】 R581.3 【文献标识码】 A 【文章编号】 1003—6350（2013）12—1735—03


Clinical value of 131I therapy in the treatment of Graves' disease.
JIANG Bing-chen 1, GAO Yong-wang 1, ZHANG
Xue-hui 1, XIAO Guo-you 2, YAO Shao-hong 1. 1. Department of Nuclear Medicine, Beihai People's Hospital, Beihai
536000, Guangxi, CHINA; 2. Department of Nuclear Medicine, the Affiliated Tumor Hospital of Guangxi Medical
University, Nanning 530021, Guangxi, CHINA

【Abstract】 Objective To investigate the clinical value of 131I therapy in the treatment of Graves' disease (dif-
fuse toxic goiter. Methods Ninety-three patients with Graves' disease were treated by 131I therapy, then the clinical
effects were observed and compared with that of antithyroid drugs (85 cases) operation (82 cases). Results The total
cure rate, the total improvement rate, the total effective rate after the first 131I therapy were 68.8%, 11.8%, 80.6%, re-
spectively. Compared with antithyroid drugs, 131I therapy had significantly higher cure rate and shorter treatment cycle,
(P<0.05). 131I therapy showed no statistically significant difference with operation in cure rate (P>0.05), but the treat-
ment costs plunged. Conclusion The treatment of Graves' disease with 131I is stable and effective, with short cycle,
low price and high security features, which is worth popularizing.