标题：2型糖尿病合并非酒精性脂肪肝的临床特点及危险因素分析

      作者：王礼文 1，陈 健 1，冯学山 2
    (1.佛山市禅城区向阳医院全科，广东 佛山 528000；
2.上海复旦大学公共卫生学院卫生统计与社会医学教研室，上海 200032)

      卷次： 2013年24卷12期

      【摘要】 目的 探讨 2型糖尿病 (T2DM)合并非酒精性脂肪肝 (NAFLD)的临床特点及其相关危险因
素。方法 随机抽取我院已建立健康档案的糖尿病患者200例，根据是否合并非酒精性脂肪肝分为两组，比较
T2DM合并NAFLD (A组，n=114)与T2DM不合并NAFLD(B组，n=86)患者之间的临床特征，探讨影响NAFLD的
危险因素。结果 两组患者体重指数（BMI）、腰围(WC)、舒张压（DBP）、甘油三酯（TG）、低密度脂蛋白胆固醇
(LDL-C)、血尿酸(UA)、血清丙氨酸转氨酶(ALT)、空腹血糖（FBG）水平比较差异有统计学意义（P<0.01或 P<
0.05）；A组代谢综合征、肥胖症、脂代谢紊乱、冠心病、高血压病的发生率明显高于 B组(P<0.01或 P<0.05)。
Logistic回归分析显示BMI、TG、UA对糖尿病合并NAFLD的发生有显著影响(均P<0.01)。结论 2型糖尿病合
并NAFLD易发生于肥胖、血脂紊乱、胰岛素抵抗人群，2型糖尿病患者的BMI、TG、UA升高是并发非酒精性脂肪
性肝病的危险因素。

      【关键词】 2型糖尿病；非酒精性脂肪肝；临床特点；危险因素

      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2013）12—1729—03


Clinical characters and risk factors of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus.
WANG Li-wen 1, CHEN Jian 1, FENG Xue-shan 2.
1. Department of Medicine, Xiangyang Hospital of Chancheng District
of Foshan City, Foshan 528000, Guangdong, CHINA; 2. Department of Health Statistics and Social Medicine, School of
Public Health, Fudan University, Shanghai 200032, CHINA

【Abstract】 Objective To investigate clinical characters and risk factors of non-alcoholic fatty liver disease
(NAFLD) in patients with type 2 diabetes mellitus (T2DM). Methods According to whether the patients had
NAFLD, 200 patients with T2DM consistent with the standard were divided into fatty liver group (group A, n=114)
and non-fatty liver group (group B, n=86). The clinical characters of group A was compared to those of group B. The
risk factors about NAFLD were analyzed by Logistic regression. Results The levels of body mass index (BMI),
waist circumference (WC), diastolic blood pressure (DBP), serum triglyceride (TG), blood uric acid (UA), alanine ami-
notransferase (ALT), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG) showed statistically
significant difference between the two groups (P<0.01 or P<0.05). Group A had significantly higher incidence of me-
tallic syndrome, obesity, dyslipidemia, coronary heart disease and hypertension than group B. Logistic regression anal-
ysis showed that BMI, TG and UA were the risk factors of NAFLD (P<0.01). Conclusion NAFLD complicated with
T2DM is prone to occur in people with obesity, dyslipidemia and IR. BMI, TG and UA are the risk factors of NAFLD