标题：转化生长因子β1基因多态性与大肠腺瘤的相关性研究

      作者：余玉红，陈出新，高赫男
    (深圳市盐田区人民医院内一科，广东 深圳 518081)

      卷次： 2013年24卷11期

      【摘要】 目的 研究转化生长因子β1 (TGF-β1)基因-509C/T、+869T/C多态性与大肠腺瘤的相关性。方法 采
用聚合酶链反应-限制性片段长度多态性方法，检测 82例大肠腺瘤患者以及 102例正常对照者 TGF-β 1基
因-509C/T、+869T/C多态性，并分析该基因多态性与大肠腺瘤临床病理特征之间的关系。结果 TGF-β1-509C/T、
+869T/C等位基因频率及基因型频率在大肠腺瘤组和对照组的总体分布差异无统计学意义。将大肠腺瘤患者按
性别分组后，大肠腺瘤女性患者与男性比较，-509TT基因型频率有增高趋势(30.3% vs 14.3%，P=0.079，OR=
2.609，95%CI：0.876~7.771)，但差异无统计学意义。结论 TGF-β1-509C/T多态性及+869T/C多态性与大肠腺
瘤易感性无关。

      【关键词】 转化生长因子β1；基因多态性；大肠腺瘤

      【中图分类号】 R735.3+4 【文献标识码】 A 【文章编号】 1003—6350（2013）11—1561—04


Association between gene polymorphisms of transforming growth factor beta 1 and colorectal adenoma.
YU
Yu-hong, CHEN Chu-xin, GAO He-nan. The First Department of Internal Medicine, People's Hospital of Yantian District
of Shenzhen City, Shenzhen 518081, Guangdong, CHINA

【Abstract】 Objective To determine the association of the -509C/T, +869T/C polymorphism of transforming
growth factor beta 1 (TGF-β1) gene with the risk of colorectal adenoma. Methods TGF-β1 gene polymorphism for
82 patients with colorectal adenoma (the study group) and 102 healthy controls (the control group) were detected by
polymerase chain reaction (PCR) and restriction analysis. Association of the genotype and allele frequencies was stud-
ied with the clinical and pathological features of colorectal adenoma. Results No significant difference was found in
genotype and allele frequency distributions between the study group and the control group. The TT genotype was
slightly higher in female adenoma patients than male adenoma patients (30.3% vs 14.3%, P=0.079, OR=2.609, 95%
CI: 0.876~7.771), but the difference was not significant. Conclusion TGF-β 1-509C/T and +869T/C polymorphism
is not associated with colorectal adenoma.

      【Key words】 Transforming growth factor beta 1; Gene polymorphism; Colorectal adenoma
基金项目：深圳市科技计划项目(编号：200803198)