标题：1 560例孕中期妇女血清学产前筛查结果分析

      作者：涂志华，黄慈丹，杨 春，朱晓妹，周小婉，王 洁
    （海南省妇幼保健院检验中心，海南 海口 570206）

      卷次： 2013年24卷8期

      【摘要】 目的 探讨孕中期妇女血清学产前筛查唐氏综合征、18-三体综合征、开放性神经管畸形筛查结果
的特点，为临床服务提供参考数据。方法 采用时间分辨免疫荧光法检测孕中期妇女血清 uE3、游离β-hCG、
AFP含量，结合孕妇年龄、体重等信息，通过Lifecycle3.2软件评估胎儿唐氏综合征、18-三体综合征、开放性神经
管畸形高危与否。孕妇产后两个月内回访妊娠结局。结果 唐氏综合征高风险阳性率为5.32%，1例高风险阳性
确诊唐氏综合征；18-三体综合征高风险阳性率为0.90%；开放性神经管畸形高风险阳性率为0.64%。唐氏综合
征高风险阳性率海南省妇幼保健院与合作医院比较，差异有统计学意义(χ2=4.72，P＜0.05)，35岁及以上组孕
妇高于 35岁以下组，两者差异有显著统计学意义(χ2=70.63，P＜0.01)，35岁以下组高风险阳性率也达 3.71%。
结论 多单位协作进行产前筛查时，应重视标本采集、运送等规范操作；每个年龄段的孕妇均应重视产前筛查。

      【关键词】 唐氏综合征；18-三体综合征；开放性神经管缺陷；产前筛查

      【中图分类号】 R446.11 【文献标识码】 A 【文章编号】 1003—6350（2013）08—1165—03


Analysis on the maternal serum prenatal screening results of 1560 pregnant women during the second trimester
of pregnancy.
TU Zhi-hua, HUANG Ci-dan, YANG Chun, ZHU Xiao-mei, ZHOU Xiao-wan, WANG Jie. Clinical
Laboratory Center, Hainan Provincial Maternity and Child Health Hospital, Haikou 570206, Hainan, CHINA

【Abstract】 Objective To investigate the characteristics of prenatal screening results for Down's syn-
drome (DS), Edward's syndrome (ES) and open neural tube defects (ONTD), and to provide reference for clin-
ical service. Methods Time-resolved fluoroimmunoassay was used to detect the count of uE3, free-β-hCG, AFP in
serum of pregnant women during the second trimester. The software Lifecycle3.2 was used to calculate the risk values
of DS, ES, ONTD by importing the data of uE3, free-β-hCG, AFP, age, body weight, et al. The pregrant women were
followed up 2 months after postpartum for pregnancy outcome. Results The positive rate of the high risk DS was
5.32%. One case of the high risk DS was diagnosed definitely. The positive rate of high risk ES was 0.90%, and the
positive rate of high risk ONTD was 0.64%. The positive rates of high risk DS of Hainan Provincial Maternity and
Child Health Hospital and cooperation hospitals were different significantly (χ 2=4.72, P<0.05). The positive rate of
high risk DS cases of≥35 year old was significantly higher than those for the patients of <35 year old (χ2=70.63, P<
0.01), The positive rate of high risk DS cases of <35 year old was 3.71%. Conclusion Standardizing of the speci-
men collection and transportation are important for the prenatal screening in hospital cooperation. Pregnant women at
any age should attach importance to prenatal screening.

      【Key words】 Down's syndrome (DS); Edward's syndrome (ES); Open neural tube defects (ONTD); Prenatal